{"id":12758,"date":"2024-06-30T12:46:59","date_gmt":"2024-06-30T03:46:59","guid":{"rendered":"https:\/\/jyakusyadansei.com\/?p=12758"},"modified":"2024-06-30T12:50:06","modified_gmt":"2024-06-30T03:50:06","slug":"%e3%80%90%e6%ad%af%e3%80%91poic%e6%b0%b4%ef%bc%88%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e5%88%86%e8%a7%a3%e5%9e%8b%e9%99%a4%e8%8f%8c%e6%b0%b4%ef%bc%89%e3%81%af%e6%80%aa%e3%81%97%e3%81%84-%e5%8a%b9","status":"publish","type":"post","link":"https:\/\/jyakusyadansei.com\/?p=12758","title":{"rendered":"\u3010\u6b6f\u3011POIC\u6c34\uff08\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u578b\u9664\u83cc\u6c34\uff09\u306f\u602a\u3057\u3044\/\u52b9\u679c\u304c\u3042\u308b\uff1f\u6b21\u4e9c\u5869\u7d20\u9178\u6c34\u3068\u306e\u9055\u3044\u306f\uff01\uff1f\u6700\u65b0\u306e\u7814\u7a76\u306b\u57fa\u3065\u304d\u5fb9\u5e95\u7684\u306b\u691c\u8a3c\u3057\u3066\u307f\u308b\u3002"},"content":{"rendered":"

POIC\u6c34\uff08\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u578b\u9664\u83cc\u6c34\uff09\u306f\u3001\u6b21\u4e9c\u5869\u7d20\u9178\u3092\u4e3b\u6210\u5206\u3068\u3059\u308b\u6297\u83cc\u6d17\u6d44\u5264\u3067\u3001\u53e3\u8154\u30b1\u30a2\u306b\u304a\u3044\u3066\u7d30\u83cc\u306e\u9664\u53bb\u3084\u6b6f\u8089\u306e\u5065\u5eb7\u7dad\u6301\u306b\u52b9\u679c\u7684\u3068\u306e\u7814\u7a76\u7d50\u679c\u304c\u591a\u304f\u51fa\u3066\u304a\u308a\u3001\u6b6f\u79d1\u533b\u63a8\u5968\u306e\u5546\u54c1\u3067\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u6b21\u4e9c\u5869\u7d20\u9178\u7cfb\u6d17\u6d44\u5264\u306e\u53e3\u8154\u306b\u304a\u3044\u3066\u306e\u6297\u83cc\u4f5c\u7528\u306f\u591a\u304f\u306e\u7814\u7a76\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u5229\u7528\u52b9\u679c\u3068\u5065\u5eb7\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u5177\u4f53\u7684\u306b\u691c\u8a3c\u3057\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

POIC\u6c34\u306e\u6297\u83cc\u52b9\u679c<\/h2>\n

\u5fae\u751f\u7269\u306e\u9664\u53bb<\/strong><\/h3>\n

\u6b21\u4e9c\u5869\u7d20\u9178\u3092\u542b\u3080POIC\u6c34\u306f\u3001\u5fae\u751f\u7269\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3084\u6b6f\u8089\u306e\u708e\u75c7\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u53e3\u8154\u5185\u306e\u7d30\u83cc\u6570\u304c\u52b9\u679c\u7684\u306b\u6e1b\u5c11\u3057\u3001\u53e3\u8154\u5185\u306e\u885b\u751f\u72b6\u614b\u304c\u6539\u5584\u3055\u308c\u307e\u3059 (Rossi-Fedele et al., 2011)<\/a>, (Pinheiro et al., 2018)<\/a>.<\/p>\n

\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u9664\u53bb<\/strong>:<\/h3>\n

\u4f4e\u6fc3\u5ea6\u306e\u6b21\u4e9c\u5869\u7d20\u9178\u6eb6\u6db2\u306f\u3001\u7fa9\u6b6f\u3084\u6b6f\u30d6\u30e9\u30b7\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u52b9\u679c\u7684\u306b\u9664\u53bb\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7d30\u83cc\u306e\u7e41\u6b96\u3092\u9632\u304e\u3001\u53e3\u8154\u5185\u306e\u6e05\u6f54\u3092\u4fdd\u3061\u307e\u3059 (Peracini et al., 2016)<\/a>.<\/p>\n

\u6b6f\u8089\u708e\u306e\u6291\u5236<\/strong><\/h3>\n

\u6b21\u4e9c\u5869\u7d20\u9178\u3092\u542b\u3080\u30de\u30a6\u30b9\u30ea\u30f3\u30b9\u306f\u3001\u6b6f\u8089\u708e\u3084\u30d7\u30e9\u30fc\u30af\u306e\u84c4\u7a4d\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u307e\u3059\u300221\u65e5\u9593\u306e\u4f7f\u7528\u5f8c\u3001\u30d7\u30e9\u30fc\u30af\u6307\u6570\u3084\u6b6f\u8089\u708e\u6307\u6570\u304c\u9855\u8457\u306b\u6539\u5584\u3055\u308c\u307e\u3057\u305f (DE NARDO et al., 2012)<\/a>.<\/p>\n

POIC\u6c34\u306e\u4f7f\u7528\u65b9\u6cd5\u3068\u6ce8\u610f\u70b9<\/h2>\n

POIC\u306f\u4ee5\u4e0b\u306e\u7528\u9014\u3067\u5229\u7528\u3057\u307e\u3059\u3002\u52b9\u679c\u306f\u7d0445\u5ea6\u3067\u6700\u3082\u9855\u73fe\u3055\u308c\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30ea\u30f3\u30b9\uff08\u53e3\u3092\u3059\u3059\u3050\uff09<\/strong><\/h3>\n

\u6b6f\u78e8\u304d\u524d\u306bPOIC\u6c34\u3067\u30ea\u30f3\u30b9\u3059\u308b\u3053\u3068\u3067\u3001\u53e3\u8154\u5185\u306e\u7d30\u83cc\u6570\u3092\u6e1b\u5c11\u3055\u305b\u3001\u6b6f\u57a2\u306e\u5f62\u6210\u3092\u9632\u304e\u307e\u3059\u3002<\/p>\n

\u6b6f\u30d6\u30e9\u30b7\u306e\u6d88\u6bd2<\/strong><\/h3>\n

\u4f7f\u7528\u5f8c\u306e\u6b6f\u30d6\u30e9\u30b7\u3092POIC\u6c34\u306b\u6d78\u3059\u3053\u3068\u3067\u3001\u7d30\u83cc\u306e\u7e41\u6b96\u3092\u9632\u304e\u307e\u3059\u3002
\n\u6b6f\u30d6\u30e9\u30b7\u306e\u6d88\u6bd2\u3092\u3059\u308b\u65b9\u306f\u5c11\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u306e\u3067\u3001POIC\u306e\u4f7f\u3044\u65b9\u3068\u3057\u3066\u306f\u8208\u5473\u6df1\u3044\u4e00\u9762\u3067\u3082\u3042\u308a\u307e\u3059(\u00b4\uff65\u03c9\uff65`)<\/p>\n

\u5165\u308c\u6b6f\u3084\u30de\u30a6\u30b9\u30ac\u30fc\u30c9\u306e\u6d17\u6d44<\/strong><\/h3>\n

\u7fa9\u6b6f\u3084\u30de\u30a6\u30b9\u30ac\u30fc\u30c9\u3092POIC\u6c34\u306b\u6d78\u3057\u3066\u6d17\u6d44\u3057\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u5f62\u6210\u3092\u6291\u5236\u3057\u307e\u3059\u3002<\/p>\n

\u6b21\u4e9c\u5869\u7d20\u9178\u6c34\u3068\u306e\u9055\u3044<\/h2>\n

\u6297\u83cc\u52b9\u679c<\/h3>\n

POIC\u6c34: POIC\u6c34\u306f\u3001\u6b21\u4e9c\u5869\u7d20\u9178\u3092\u542b\u3080\u6c34\u6eb6\u6db2\u3067\u3042\u308a\u3001\u5f37\u529b\u306a\u6297\u83cc\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u53e3\u8154\u5185\u306e\u7d30\u83cc\u6570\u3092\u6e1b\u5c11\u3055\u305b\u3001\u6b6f\u57a2\u3084\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u5f62\u6210\u3092\u9632\u304e\u307e\u3059\u3002POIC\u6c34\u306f\u7279\u306b\u3001\u6b6f\u8089\u708e\u3084\u6b6f\u5468\u75c5\u306e\u4e88\u9632\u306b\u52b9\u679c\u7684\u3067\u3059 (Rossi-Fedele et al., 2011), (Pinheiro et al., 2018).<\/p>\n

\u6b21\u4e9c\u5869\u7d20\u9178\u6c34: \u6b21\u4e9c\u5869\u7d20\u9178\u6c34\u3082\u5e83\u7bc4\u306a\u6297\u83cc\u52b9\u679c\u3092\u6301\u3061\u3001\u591a\u304f\u306e\u53e3\u8154\u5185\u75c5\u539f\u83cc\u306b\u5bfe\u3057\u3066\u6709\u52b9\u3067\u3059\u3002\u6b21\u4e9c\u5869\u7d20\u9178\u6c34\u306f\u3001\u521d\u671f\u6bb5\u968e\u3067\u306e\u7d30\u83cc\u6e1b\u5c11\u306b\u52b9\u679c\u304c\u3042\u308a\u3001\u7279\u306b\u6297\u30d7\u30e9\u30fc\u30af\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059 (Lafaurie et al., 2018).<\/p>\n

\u6301\u7d9a\u6027<\/h3>\n

POIC\u6c34\u306f\u300110~15ml\u3092\u4f7f\u7528\u3057\u30661\u65e52\u56de\u30ea\u30f3\u30b9\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u52b9\u679c\u306f\u6301\u7d9a\u7684\u3067\u3059\u3002<\/p>\n

\u6b21\u4e9c\u5869\u7d20\u9178\u6c34\u306f\u3001\u4f4e\u6fc3\u5ea6\u3067\u306e\u4f7f\u7528\u3067\u3082\u521d\u671f\u306e\u6297\u83cc\u52b9\u679c\u304c\u9ad8\u3044\u3067\u3059\u304c\u3001\u305d\u306e\u52b9\u679c\u306f\u77ed\u6642\u9593\u3067\u6e1b\u5c11\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u300130\u79d2\u9593\u306e\u30ea\u30f3\u30b9\u3067\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u304c\u30011\u6642\u9593\u5f8c\u306b\u306f\u7d30\u83cc\u6570\u304c\u5143\u306b\u623b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5065\u5eb7\u88ab\u5bb3\u306e\u61f8\u5ff5<\/h2>\n

\u6d88\u6bd2\u526f\u751f\u6210\u7269\u306e\u30ea\u30b9\u30af<\/strong><\/h3>\n

\u5869\u7d20\u3092\u4f7f\u7528\u3057\u305f\u6c34\u306e\u6d88\u6bd2\u3067\u306f\u3001\u30c8\u30ea\u30cf\u30ed\u30e1\u30bf\u30f3\uff08THM\uff09\u3084\u30cf\u30ed\u9162\u9178\uff08HAA\uff09\u306a\u3069\u306e\u6d88\u6bd2\u526f\u751f\u6210\u7269\uff08DBP\uff09\u304c\u751f\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u9577\u671f\u7684\u306a\u66dd\u9732\u306b\u3088\u308a\u3001\u767a\u304c\u3093\u6027\u3084\u305d\u306e\u4ed6\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u61f8\u5ff5\u3055\u308c\u3066\u3044\u307e\u3059 (Gopal et al., 2007)<\/a>.<\/p>\n

\u8033\u3078\u306e\u6bd2\u6027<\/strong><\/h3>\n

\u52d5\u7269\u5b9f\u9a13\u306b\u304a\u3044\u3066\u3001\u6b21\u4e9c\u5869\u7d20\u9178\u304c\u5185\u8033\u306b\u5bfe\u3057\u3066\u6f5c\u5728\u7684\u306a\u6bd2\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u8074\u899a\u95be\u5024\u306e\u60aa\u5316\u3084\u7d44\u7e54\u306e\u640d\u50b7\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f (Mutlu et al., 2022)<\/a>.<\/p>\n

\u7d30\u80de\u6bd2\u6027\u3068\u767a\u304c\u3093\u6027<\/strong><\/h3>\n

\u6b21\u4e9c\u5869\u7d20\u9178\u3084\u305d\u306e\u526f\u751f\u6210\u7269\u306f\u3001\u7d30\u80de\u6bd2\u6027\u3084\u767a\u304c\u3093\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u30e2\u30ce\u30cf\u30ed\u9162\u9178\uff08monoHAA\uff09\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u708e\u75c7\u3084\u767a\u304c\u3093\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059 (Pals et al., 2013)<\/a>.<\/p>\n

\u7d50\u8ad6<\/h2>\n

POIC\u6c34\uff08\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u578b\u9664\u83cc\u6c34\uff09\u306f\u3001\u53e3\u8154\u30b1\u30a2\u306b\u304a\u3044\u3066\u52b9\u679c\u7684\u306a\u6297\u83cc\u5264\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9069\u5207\u306a\u6fc3\u5ea6\u3068\u4f7f\u7528\u65b9\u6cd5\u3092\u5b88\u308b\u3053\u3068\u3067\u3001\u53e3\u8154\u5185\u306e\u885b\u751f\u3092\u4fdd\u3061\u3001\u7d30\u83cc\u611f\u67d3\u3092\u9632\u3050\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n

\u5065\u5eb7\u88ab\u5bb3\u306e\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3067\u3059\u304c\u3001\u6fc3\u5ea6\u3092\u4f4e\u304f\u3059\u308b\u306a\u3069\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5b89\u5fc3\u3057\u3066\u5229\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046(\u00b4\uff65\u03c9\uff65`)<\/p>\n","protected":false},"excerpt":{"rendered":"

POIC\u6c34\uff08\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u578b\u9664\u83cc\u6c34\uff09\u306f\u3001\u6b21\u4e9c\u5869\u7d20\u9178\u3092\u4e3b\u6210\u5206\u3068\u3059\u308b\u6297\u83cc\u6d17\u6d44\u5264\u3067\u3001\u53e3\u8154\u30b1\u30a2\u306b\u304a\u3044\u3066\u7d30\u83cc\u306e\u9664\u53bb\u3084\u6b6f\u8089\u306e\u5065\u5eb7\u7dad\u6301\u306b\u52b9\u679c\u7684\u3068\u306e\u7814\u7a76\u7d50\u679c\u304c\u591a\u304f\u51fa\u3066\u304a\u308a\u3001\u6b6f\u79d1\u533b\u63a8\u5968\u306e\u5546\u54c1\u3067\u3082\u3042\u308a\u307e\u3059\u3002 \u6b21\u4e9c\u5869\u7d20\u9178\u7cfb\u6d17\u6d44\u5264\u306e\u53e3\u8154\u306b\u304a\u3044\u3066\u306e […]<\/p>\n","protected":false},"author":2,"featured_media":12762,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7],"tags":[],"class_list":["post-12758","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-7"],"acf":[],"_links":{"self":[{"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/posts\/12758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12758"}],"version-history":[{"count":3,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/posts\/12758\/revisions"}],"predecessor-version":[{"id":12765,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/posts\/12758\/revisions\/12765"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/media\/12762"}],"wp:attachment":[{"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}