{"id":17517,"date":"2026-03-27T20:46:25","date_gmt":"2026-03-27T11:46:25","guid":{"rendered":"https:\/\/jyakusyadansei.com\/?p=17517"},"modified":"2026-03-27T20:46:25","modified_gmt":"2026-03-27T11:46:25","slug":"%e8%80%81%e5%8c%96%e3%81%af%e6%ad%a2%e3%82%81%e3%82%89%e3%82%8c%e3%82%8b%ef%bc%9f-longevity%ef%bc%88%e3%83%ad%e3%83%b3%e3%82%b8%e3%82%a7%e3%83%93%e3%83%86%e3%82%a3%ef%bc%89%e5%ae%8c%e5%85%a8%e8%a7%a3","status":"publish","type":"post","link":"https:\/\/jyakusyadansei.com\/?p=17517","title":{"rendered":"\u8001\u5316\u306f\u6b62\u3081\u3089\u308c\u308b\uff1f Longevity\uff08\u30ed\u30f3\u30b8\u30a7\u30d3\u30c6\u30a3\uff09\u5b8c\u5168\u89e3\u8aac\uff5c\u7d30\u80de\u30ec\u30d9\u30eb\u306e12\u306e\u8001\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u81e8\u5e8a\u5bfe\u7b56\u3092\u5fb9\u5e95\u56f3\u89e3"},"content":{"rendered":"

 <\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u2728 \u307b\u306e\u307c\u306e Longevity \u8b1b\u5ea7\u3001\u958b\u8b1b\u3058\u3083 \u2728\ud83d\udc3b\u200d\u2744\ufe0f<\/p>\n

\ud83e\uddf8\u300c\u3057\u308d\u304f\u307e\u3061\u3083\u3093\u3001Longevity\u3063\u3066\u7d50\u5c40\u3001\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3068\u306f\u9055\u3046\u306e\uff1f \u30b5\u30d7\u30ea\u3068\u304b\u9ad8\u7d1a\u30af\u30ea\u30fc\u30e0\u306e\u8a71\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8c\uff6b\uff8c\uff6b\u3001\u30c6\u30c7\u30a3\u3088\u3001\u3044\u3044\u8cea\u554f\u3058\u3083\u306e\u3002\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3068\u805e\u304f\u3068”\u30b7\u30ef\u3092\u6d88\u3059””\u82e5\u8fd4\u308a\u306e\u9b54\u6cd5”\u307f\u305f\u3044\u306a\u97ff\u304d\u304c\u3042\u308b\u304c\u3001Longevity\u306e\u672c\u8cea\u306f\u305d\u3053\u3067\u306f\u306a\u3044\u306e\u3058\u3083\u3002Longevity\u3068\u306f\u3001\u8001\u5316\u3068\u3044\u3046\u73fe\u8c61\u304c\u4f53\u306e\u4e2d\u3067\u3069\u3046\u9032\u3080\u306e\u304b\u3092\u79d1\u5b66\u7684\u306b\u7406\u89e3\u3057\u3066\u3001\u65e5\u5e38\u306e\u7a4d\u307f\u91cd\u306d\u3092\u6700\u9069\u5316\u3057\u3066\u3044\u304f\u8003\u3048\u65b9\u306a\u306e\u3058\u3083\u3088\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\ud83e\uddf8\u300c\u82e5\u8fd4\u308a\u306e\u9b54\u6cd5\u3058\u3083\u306a\u304f\u3066\u3001\u4ed5\u7d44\u307f\u3092\u77e5\u3063\u3066\u5bfe\u7b56\u3059\u308b\u3001\u3063\u3066\u3053\u3068\u304b\uff5e\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u305d\u3046\u3044\u3046\u3053\u3068\u3058\u3083\u3002\u9b54\u6cd5\u306e\u85ac\u3092\u63a2\u3059\u3093\u3058\u3083\u306a\u304f\u3001”\u306a\u305c\u8001\u3044\u308b\u306e\u304b”\u3092\u7406\u89e3\u3057\u3066\u3001\u6bce\u65e5\u306e\u66ae\u3089\u3057\u306e\u4e2d\u3067\u5c11\u3057\u305a\u3064\u624b\u3092\u6253\u3063\u3066\u3044\u304f\u3002\u305d\u308c\u304cLongevity\u306e\u771f\u9ac4\u306a\u306e\u3058\u3083\u3088\u2728\u300d<\/p>\n

\n

\ud83d\udc3b\u200d\u2744\ufe0f\u2744\ufe0f Longevity\u306e\u300c\u4e8c\u5c64\u69cb\u9020\u300d\u3092\u77e5\u308b\u306e\u3058\u3083<\/h2>\n

\u3055\u3066\u3001\u3053\u306eLongevity\u3068\u3044\u3046\u5206\u91ce\u3001\u5b9f\u306f\u5927\u304d\u304f\u4e8c\u3064\u306e\u5c64\u306b\u5206\u3051\u3066\u7406\u89e3\u3059\u308b\u3068\u975e\u5e38\u306b\u30b9\u30c3\u30ad\u30ea\u3059\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u7b2c1\u5c64\u306f\u300c\u57fa\u790e\u8001\u5316\u751f\u7269\u5b66\uff08Hallmarks of Aging\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u9818\u57df\u3067\u3001\u7d30\u80de\u3084\u7d44\u7e54\u306e\u4e2d\u3067\u8001\u5316\u304c\u3069\u3046\u9032\u3080\u304b\u3092\u6271\u3046\u5b66\u554f\u3058\u3083\u3002\u3053\u308c\u306f2013\u5e74\u306b\u30b9\u30da\u30a4\u30f3\u30fb\u30aa\u30d3\u30a8\u30c9\u5927\u5b66\u306eCarlos L\u00f3pez-Ot\u00edn\u3089\u304c\u5b66\u8853\u8a8c\u300eCell\u300f\u306b\u767a\u8868\u3057\u305f\u8ad6\u6587\u304c\u51fa\u767a\u70b9\u306b\u306a\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u5f7c\u3089\u306f\u307e\u305a9\u3064\u306e\u300c\u8001\u5316\u306e\u7279\u5fb4\uff08Hallmarks\uff09\u300d\u3092\u5b9a\u7fa9\u3057\u305f\u306e\u3058\u3083\u304c\u3001\u305d\u306e\u5f8c10\u5e74\u9593\u306e\u7814\u7a76\u6210\u679c\u3092\u8e0f\u307e\u3048\u30012023\u5e74\u306b\u540c\u3058\u304f\u300eCell\u300f\u8a8c\u3067\u6539\u8a02\u7248\u3092\u767a\u8868\u3057\u30013\u3064\u3092\u8ffd\u52a0\u3057\u3066\u5408\u8a0812\u306e\u7279\u5fb4\u306b\u62e1\u5f35\u3057\u305f\u306e\u3058\u3083\u3088\u3002<\/p>\n

\ud83e\uddf8\u300c9\u3064\u3060\u3063\u305f\u306e\u304c12\u306b\u5897\u3048\u305f\u306e\uff1f 10\u5e74\u3067\u305d\u3093\u306a\u306b\u7814\u7a76\u304c\u9032\u3093\u3060\u3093\u3060\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u305d\u3046\u3058\u3083\u3002\u8ffd\u52a0\u3055\u308c\u305f3\u3064\u306f”\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6a5f\u80fd\u4e0d\u5168””\u6162\u6027\u708e\u75c7””\u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9\uff08\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4e71\u308c\uff09”\u3067\u3001\u3044\u305a\u308c\u3082\u5143\u306e9\u3064\u306e\u4e2d\u306b\u542b\u307e\u308c\u3066\u3044\u305f\u6982\u5ff5\u3092\u3088\u308a\u7cbe\u5bc6\u306b\u72ec\u7acb\u3055\u305b\u305f\u3082\u306e\u306a\u306e\u3058\u3083\u3002\u3061\u306a\u307f\u306bL\u00f3pez-Ot\u00edn\u3089\u304c\u5b9a\u3081\u305fHallmark\u306e\u8a8d\u5b9a\u57fa\u6e96\u306f3\u3064\u3042\u3063\u3066\u306e\u3002\u2460\u52a0\u9f62\u3068\u3068\u3082\u306b\u73fe\u308c\u308b\u3053\u3068\u3001\u2461\u305d\u308c\u3092\u5b9f\u9a13\u7684\u306b\u60aa\u5316\u3055\u305b\u308b\u3068\u8001\u5316\u304c\u52a0\u901f\u3059\u308b\u3053\u3068\u3001\u2462\u6cbb\u7642\u7684\u306b\u4ecb\u5165\u3059\u308c\u3070\u8001\u5316\u3092\u9045\u3089\u305b\u305f\u308a\u6b62\u3081\u305f\u308a\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u9006\u8ee2\u3055\u305b\u3089\u308c\u308b\u3053\u3068\u2015\u2015\u3053\u306e3\u6761\u4ef6\u3092\u6e80\u305f\u3059\u3082\u306e\u3060\u3051\u304cHallmark\u3068\u8a8d\u3081\u3089\u308c\u308b\u306e\u3058\u3083\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\u305d\u3057\u3066\u7b2c2\u5c64\u304c\u300c\u81e8\u5e8aLongevity\u300d\u3067\u3001\u7b2c1\u5c64\u3067\u89e3\u660e\u3055\u308c\u305f\u8001\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u77e5\u8b58\u3092\u4f7f\u3063\u3066\u3001\u5b9f\u969b\u306b\u75c5\u6c17\u3084\u6a5f\u80fd\u4f4e\u4e0b\u3092\u9632\u304e\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u305f\u3081\u306e\u5b9f\u8df5\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u6271\u3046\u5206\u91ce\u306a\u306e\u3058\u3083\u3002\u3064\u307e\u308a\u3001\u7b2c1\u5c64\u304c\u300c\u4f53\u306e\u4e2d\u3067\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\u304b\u300d\u306e\u5730\u56f3\u306a\u3089\u3001\u7b2c2\u5c64\u306f\u300c\u305d\u306e\u5730\u56f3\u3092\u898b\u306a\u304c\u3089\u3001\u65e5\u5e38\u751f\u6d3b\u3067\u3069\u3046\u52d5\u304f\u304b\u300d\u306e\u30ca\u30d3\u30b2\u30fc\u30b7\u30e7\u30f3\u3068\u3044\u3046\u308f\u3051\u3062\u3083\u3002<\/p>\n

\n

\ud83d\udc3b\u200d\u2744\ufe0f\ud83d\udd2c \u7b2c1\u5c64\uff1a\u57fa\u790e\u8001\u5316\u751f\u7269\u5b66 \uff5e 12\u306eHallmarks of Aging \uff5e<\/h2>\n

\u57fa\u790e\u8001\u5316\u751f\u7269\u5b66\u304c\u307e\u305a\u6559\u3048\u3066\u304f\u308c\u308b\u306e\u306f\u3001\u8001\u5316\u306f\u5358\u4e00\u306e\u539f\u56e0\u3067\u8d77\u3053\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u3044\u304f\u3064\u3082\u306e\u5c0f\u3055\u306a\u7570\u5e38\u304c\u7d61\u307f\u5408\u3044\u3001\u60aa\u5faa\u74b0\u3092\u5f62\u6210\u3057\u306a\u304c\u3089\u9032\u884c\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3058\u3083\u3002\u3053\u3053\u304b\u3089\u306f12\u306eHallmark\u3092\u3072\u3068\u3064\u305a\u3064\u3001\u308f\u3057\u304c\u4e01\u5be7\u306b\u89e3\u304d\u307b\u3050\u3057\u3066\u3044\u304f\u305e\u3044\u3002<\/p>\n

\n

\u2744\ufe0f\u2460 \u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\uff08Genomic Instability\uff09<\/h3>\n

\u308f\u3057\u3089\u306e\u4f53\u306e\u7d30\u80de\u306f\u6bce\u65e5\u81a8\u5927\u306a\u6570\u306eDNA\u640d\u50b7\u3092\u53d7\u3051\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u7d2b\u5916\u7dda\u3001\u6d3b\u6027\u9178\u7d20\u3001\u4ee3\u8b1d\u306e\u526f\u7523\u7269\u3001\u305d\u3057\u3066\u7d30\u80de\u5206\u88c2\u6642\u306e\u30b3\u30d4\u30fc\u30a8\u30e9\u30fc\u3002\u82e5\u3044\u3046\u3061\u306f\u4fee\u5fa9\u30b7\u30b9\u30c6\u30e0\u304c\u3057\u3063\u304b\u308a\u50cd\u3044\u3066\u50b7\u3092\u76f4\u3057\u3066\u304f\u308c\u308b\u306e\u3058\u3083\u304c\u3001\u5e74\u3092\u91cd\u306d\u308b\u3068\u3053\u306e\u4fee\u5fa9\u306e\u7cbe\u5ea6\u304c\u843d\u3061\u3066\u304f\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u305f\u3068\u3048\u308b\u306a\u3089\u3001\u8a2d\u8a08\u56f3\u3092\u4f55\u5343\u56de\u3082\u30b3\u30d4\u30fc\u3057\u7d9a\u3051\u308b\u3046\u3061\u306b\u3001\u3060\u3093\u3060\u3093\u6587\u5b57\u304c\u304b\u3059\u308c\u305f\u308a\u3001\u7dda\u304c\u30ba\u30ec\u305f\u308a\u3057\u3066\u3044\u304f\u3088\u3046\u306a\u3082\u306e\u3062\u3083\u306e\u3002L\u00f3pez-Ot\u00edn\u3089\u306e2013\u5e74\u306e\u8ad6\u6587\u3067\u3082\u3001DNA\u4fee\u5fa9\u6a5f\u69cb\u306e\u6b20\u640d\u304c\u30de\u30a6\u30b9\u306e\u65e9\u8001\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308b\u3057\u3001\u9006\u306bDNA\u4fee\u5fa9\u95a2\u9023\u306e\u30bf\u30f3\u30d1\u30af\u8ceaBubR1\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u305f\u30de\u30a6\u30b9\u3067\u306f\u5065\u5eb7\u5bff\u547d\u304c\u5ef6\u3073\u305f\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u3055\u3089\u306b\u3001\u54fa\u4e73\u985e\u306e\u7a2e\u9593\u6bd4\u8f03\u7814\u7a76\u306b\u3088\u308c\u3070\u3001\u9577\u5bff\u306a\u7a2e\u307b\u3069DNA\u4fee\u5fa9\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5f37\u5316\u3055\u308c\u3066\u304a\u308a\u3001SIRT6\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u305d\u306e\u7a2e\u9593\u5dee\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u304a\u308b\u305e\u3044\u3002<\/p>\n

\ud83e\uddf8\u300c\u3064\u307e\u308aDNA\u306e\u4fee\u7406\u5de5\u304c\u75b2\u308c\u3066\u30df\u30b9\u304c\u5897\u3048\u308b\u3063\u3066\u3053\u3068\u3060\u306d\u3002\u8a2d\u8a08\u56f3\u304c\u58ca\u308c\u305f\u3089\u3001\u305d\u308a\u3083\u5de5\u5834\u3082\u304a\u304b\u3057\u304f\u306a\u308b\u3088\u306d\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u305d\u306e\u901a\u308a\u3058\u3083\u3002\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u306f\u304c\u3093\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u3082\u76f4\u7d50\u3057\u3066\u304a\u308b\u3057\u3001\u4ed6\u306e\u3059\u3079\u3066\u306eHallmark\u306e\u571f\u53f0\u306b\u3082\u306a\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3088\u2728\u300d<\/p>\n

\n

\u2744\ufe0f\u2461 \u30c6\u30ed\u30e1\u30a2\u77ed\u7e2e\uff08Telomere Attrition\uff09<\/h3>\n

\u67d3\u8272\u4f53\u306e\u672b\u7aef\u306b\u306f\u30c6\u30ed\u30e1\u30a2\u3068\u3044\u3046\u4fdd\u8b77\u30ad\u30e3\u30c3\u30d7\u304c\u3064\u3044\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u9774\u7d10\u306e\u5148\u7aef\u306b\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u306e\u30ab\u30d0\u30fc\u304c\u3064\u3044\u3066\u3044\u308b\u306e\u3092\u60f3\u50cf\u3057\u3066\u3082\u3089\u3046\u3068\u308f\u304b\u308a\u3084\u3059\u3044\u304b\u306e\u3002\u7d30\u80de\u304c\u5206\u88c2\u3059\u308b\u305f\u3073\u306b\u3053\u306e\u30ad\u30e3\u30c3\u30d7\u304c\u5c11\u3057\u305a\u3064\u77ed\u304f\u306a\u308a\u3001\u4e00\u5b9a\u4ee5\u4e0a\u77ed\u304f\u306a\u308b\u3068\u7d30\u80de\u306f\u3082\u3046\u5206\u88c2\u3067\u304d\u306a\u304f\u306a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u3053\u3053\u3067\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u3068\u3044\u3046\u9175\u7d20\u306e\u5b58\u5728\u3058\u3083\u3002\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u306f\u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055\u3092\u7dad\u6301\u30fb\u4fee\u5fa9\u3059\u308b\u9175\u7d20\u306a\u306e\u3058\u3083\u304c\u3001\u901a\u5e38\u306e\u4f53\u7d30\u80de\u3067\u306f\u307b\u3068\u3093\u3069\u6d3b\u6027\u5316\u3055\u308c\u3066\u304a\u3089\u306c\u306e\u3058\u3083\u3002\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u3067\u306f\u65e9\u671f\u8001\u5316\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308b\u3057\u30012025\u5e74\u306e\u7814\u7a76\u8ad6\u6587\u3067\u306f\u3001\u30c6\u30ed\u30e1\u30a2\u77ed\u7e2e\u3053\u305d\u304c12\u306eHallmark\u306e\u4e2d\u3067\u552f\u4e00\u306e\u300c\u539f\u56e0\u300d\u3067\u3042\u308a\u3001\u4ed6\u306f\u3059\u3079\u3066\u305d\u306e\u7d50\u679c\u3067\u3042\u308b\u3068\u3059\u308b\u5927\u80c6\u306a\u4eee\u8aac\u307e\u3067\u63d0\u51fa\u3055\u308c\u3066\u304a\u308b\u305e\u3044\u3002\u3053\u306e\u4eee\u8aac\u304c\u6b63\u3057\u3044\u304b\u3069\u3046\u304b\u306f\u307e\u3060\u8b70\u8ad6\u306e\u9014\u4e2d\u3058\u3083\u304c\u3001\u30c6\u30ed\u30e1\u30a2\u304c\u8001\u5316\u306e\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u306e\u306f\u9593\u9055\u3044\u306a\u3044\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u9774\u5e95\u304c\u3059\u308a\u6e1b\u3063\u3066\u3044\u304f\u306e\u306b\u8fd1\u3044\u3093\u3060\u306d\u3002\u6b69\u3051\u3070\u6b69\u304f\u307b\u3069\u8584\u304f\u306a\u3063\u3061\u3083\u3046\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8c\uff6b\uff8c\uff6b\u3001\u307e\u3055\u306b\u305d\u3046\u3044\u3046\u30a4\u30e1\u30fc\u30b8\u3058\u3083\u3002\u9774\u5e95\u304c\u5b8c\u5168\u306b\u3059\u308a\u6e1b\u3063\u305f\u3089\u3001\u3082\u3046\u6b69\u3051\u306a\u304f\u306a\u308b\u3062\u3083\u308d\uff1f \u7d30\u80de\u3082\u540c\u3058\u3067\u3001\u30c6\u30ed\u30e1\u30a2\u304c\u9650\u754c\u307e\u3067\u77ed\u304f\u306a\u308b\u3068\u5206\u88c2\u3092\u505c\u6b62\u3057\u3001\u8001\u5316\u7d30\u80de\uff08\u30bb\u30cd\u30c3\u30bb\u30f3\u30c8\u30fb\u30bb\u30eb\uff09\u3078\u3068\u5909\u8c8c\u3059\u308b\u306e\u3058\u3083\u3088\u300d<\/p>\n

\n

\u2744\ufe0f\u2462 \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\uff08Epigenetic Alterations\uff09<\/h3>\n

DNA\u306e\u914d\u5217\u305d\u306e\u3082\u306e\u306f\u5909\u308f\u3089\u306a\u304f\u3066\u3082\u3001\u300c\u3069\u306e\u907a\u4f1d\u5b50\u3092\u3044\u3064\u3001\u3069\u306e\u304f\u3089\u3044\u4f7f\u3046\u304b\u300d\u3092\u5236\u5fa1\u3059\u308b\u30b9\u30a4\u30c3\u30c1\u306e\u4f53\u7cfb\u304c\u72c2\u3063\u3066\u3044\u304f\u73fe\u8c61\u304c\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\u306a\u306e\u3058\u3083\u3002\u5143\u6295\u7a3f\u3067\u300c\u697d\u8b5c\u306f\u540c\u3058\u3067\u3082\u3001\u6f14\u594f\u306e\u3057\u304b\u305f\u304c\u5d29\u308c\u3066\u3044\u304f\u300d\u3068\u8868\u73fe\u3055\u308c\u3066\u304a\u3063\u305f\u304c\u3001\u3053\u308c\u306f\u975e\u5e38\u306b\u7684\u78ba\u306a\u305f\u3068\u3048\u3058\u3083\u306e\u3002<\/p>\n

\u5177\u4f53\u7684\u306b\u306fDNA\u306e\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u306e\u5909\u5316\u3084\u30d2\u30b9\u30c8\u30f3\u306e\u30a2\u30bb\u30c1\u30eb\u5316\u7570\u5e38\u304c\u52a0\u9f62\u3068\u3068\u3082\u306b\u84c4\u7a4d\u3057\u3066\u3044\u304f\u306e\u3058\u3083\u3002DNA\u30e1\u30c1\u30eb\u5316\u306e\u30d1\u30bf\u30fc\u30f3\u306f\u3044\u307e\u3084\u300c\u751f\u7269\u5b66\u7684\u5e74\u9f62\u6642\u8a08\uff08\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u30af\u30ed\u30c3\u30af\uff09\u300d\u3068\u3057\u3066\u5e83\u304f\u4f7f\u308f\u308c\u3066\u304a\u308b\u307b\u3069\u3067\u3001\u5b9f\u5e74\u9f62\u3068\u751f\u7269\u5b66\u7684\u5e74\u9f62\u306e\u30ae\u30e3\u30c3\u30d7\u3092\u6e2c\u308b\u6307\u6a19\u306b\u306a\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u91cd\u8981\u306a\u306e\u306f\u3001DNA\u5909\u7570\u3068\u9055\u3063\u3066\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\u306f\u7406\u8ad6\u4e0a\u306f\u53ef\u9006\u7684\u3060\u3068\u3044\u3046\u3053\u3068\u3058\u3083\u30022013\u5e74\u306eL\u00f3pez-Ot\u00edn\u3089\u306e\u539f\u8ad6\u6587\u3067\u3082\u3001\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u963b\u5bb3\u5264\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u52a0\u9f62\u306b\u4f34\u3046\u8a18\u61b6\u969c\u5bb3\u304c\u30de\u30a6\u30b9\u3067\u56de\u907f\u3055\u308c\u305f\u4e8b\u4f8b\u3084\u3001\u30d2\u30b9\u30c8\u30f3\u30a2\u30bb\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\u304c\u65e9\u8001\u75c7\u30de\u30a6\u30b9\u306e\u5bff\u547d\u3092\u5ef6\u4f38\u3057\u305f\u4e8b\u4f8b\u304c\u7d39\u4ecb\u3055\u308c\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u3055\u3089\u306b\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001\u7dda\u866b\uff08C. elegans\uff09\u3067\u306f\u7279\u5b9a\u306e\u30af\u30ed\u30de\u30c1\u30f3\u4fee\u98fe\u3092\u64cd\u4f5c\u3059\u308b\u3053\u3068\u3067\u3001\u89aa\u304b\u3089\u5b50\u3078\u306e\u300c\u9577\u5bff\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u8a18\u61b6\u300d\u304c\u4e16\u4ee3\u3092\u8d85\u3048\u3066\u4f1d\u9054\u3055\u308c\u308b\u3053\u3068\u304c\u767a\u898b\u3055\u308c\u3066\u304a\u308b\u305e\u3044\u3002<\/p>\n

\ud83e\uddf8\u300c\u3048\u3001\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u3063\u3066\u623b\u305b\u308b\u306e\uff1f \u305d\u308c\u3063\u3066\u3059\u3054\u304f\u306a\u3044\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u3058\u3083\u308d\uff1f \u3060\u304b\u3089\u3053\u305d\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306fLongevity\u7814\u7a76\u3067\u6700\u3082\u30db\u30c3\u30c8\u306a\u9818\u57df\u306e\u3072\u3068\u3064\u306a\u306e\u3058\u3083\u3002\u904b\u52d5\u3001\u65ad\u98df\u3001\u7279\u5b9a\u306e\u690d\u7269\u7531\u6765\u5316\u5408\u7269\u304c\u30a8\u30d4\u30b2\u30ce\u30e0\u306e”\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0”\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3082\u6307\u6458\u3055\u308c\u3066\u304a\u308b\u305e\u3044\ud83c\udf1f\u300d<\/p>\n

\n

\u2744\ufe0f\u2463 \u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u306e\u7834\u7dbb\uff08Loss of Proteostasis\uff09<\/h3>\n

\u4f53\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u4f5c\u3089\u308c\u3001\u6b63\u3057\u304f\u6298\u308a\u305f\u305f\u307e\u308c\u3001\u6a5f\u80fd\u3092\u679c\u305f\u3057\u3001\u4e0d\u8981\u306b\u306a\u3063\u305f\u3089\u5206\u89e3\u30fb\u30ea\u30b5\u30a4\u30af\u30eb\u3055\u308c\u308b\u3068\u3044\u3046\u7cbe\u5bc6\u306a\u30b5\u30a4\u30af\u30eb\u306e\u4e2d\u3067\u7ba1\u7406\u3055\u308c\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u3053\u306e\u54c1\u8cea\u7ba1\u7406\u30b7\u30b9\u30c6\u30e0\u3092\u300c\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u300d\u3068\u547c\u3076\u306e\u3058\u3083\u304c\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u3053\u306e\u4ed5\u7d44\u307f\u304c\u5f31\u304f\u306a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u5143\u6295\u7a3f\u306e\u300c\u5de5\u5834\u306e\u54c1\u8cea\u7ba1\u7406\u304c\u843d\u3061\u3066\u3001\u4e0d\u826f\u54c1\u304c\u5897\u3048\u308b\u72b6\u614b\u300d\u3068\u3044\u3046\u305f\u3068\u3048\u306f\u5b9f\u306b\u898b\u4e8b\u306a\u306e\u3058\u3083\u3002\u6298\u308a\u305f\u305f\u307f\u306b\u5931\u6557\u3057\u305f\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3001\u305d\u308c\u81ea\u4f53\u304c\u6bd2\u6027\u3092\u6301\u3061\u3001\u7279\u306b\u8133\u306b\u304a\u3044\u3066\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u3088\u3046\u306a\u51dd\u96c6\u4f53\u3068\u3057\u3066\u795e\u7d4c\u7d30\u80de\u3092\u7834\u58ca\u3057\u3066\u3044\u304f\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u8133\u306e\u75c5\u6c17\u3068\u76f4\u7d50\u3057\u3066\u308b\u3093\u3060\u2026\u6016\u3044\u306d\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u305d\u3046\u306a\u306e\u3058\u3083\u3002\u3057\u304b\u3057\u306e\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u6442\u53d6\u3001\u9593\u6b20\u7684\u65ad\u98df\uff08\u30a4\u30f3\u30bf\u30fc\u30df\u30c3\u30c6\u30f3\u30c8\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff09\u3001\u305d\u3057\u3066\u3057\u3063\u304b\u308a\u3068\u3057\u305f\u7761\u7720\u304c\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u306e\u7dad\u6301\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308b\u305e\u3044\u3002\u7761\u7720\u4e2d\u306b\u8133\u306e\u30b0\u30ea\u30f3\u30d1\u30c6\u30a3\u30c3\u30af\u30fb\u30b7\u30b9\u30c6\u30e0\u304c\u6d3b\u6027\u5316\u3057\u3066\u3001\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6d17\u3044\u6d41\u3057\u3066\u304f\u308c\u308b\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308b\u306e\u3058\u3083\u3002\u7761\u7720\u306f\u6020\u60f0\u3067\u306f\u306a\u3044\u3001\u7d30\u80de\u306e\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u6642\u9593\u306a\u306e\u3058\u3083\u3088\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\n

\u2744\ufe0f\u2464 \u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u4e0d\u5168\uff08Disabled Macroautophagy\uff09<\/h3>\n

\u3053\u308c\u304c2023\u5e74\u306e\u6539\u8a02\u3067\u5143\u3005\u2463\u306e\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u306e\u4e00\u90e8\u3068\u3057\u3066\u6271\u308f\u308c\u3066\u3044\u305f\u3082\u306e\u304b\u3089\u72ec\u7acb\u6607\u683c\u3057\u305fHallmark\u3058\u3083\u3002\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3068\u306f\u3001\u7d30\u80de\u5185\u306e\u53e4\u304f\u306a\u3063\u305f\u308a\u58ca\u308c\u305f\u308a\u3057\u305f\u90e8\u54c1\u3092\u819c\u3067\u5305\u307f\u8fbc\u307f\u3001\u30ea\u30bd\u30bd\u30fc\u30e0\uff08\u5206\u89e3\u5de5\u5834\uff09\u306b\u904b\u3093\u3067\u51e6\u5206\u3059\u308b\u30ea\u30b5\u30a4\u30af\u30eb\u30fb\u30b7\u30b9\u30c6\u30e0\u306e\u3053\u3068\u306a\u306e\u3058\u3083\u3002<\/p>\n

L\u00f3pez-Ot\u00edn\u3089\u304c\u72ec\u7acb\u3055\u305b\u305f\u7406\u7531\u306f\u660e\u5feb\u3067\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u3051\u3067\u306a\u304f\u3001\u8102\u8cea\u5c0f\u80de\u3084\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u3001\u3055\u3089\u306b\u306f\u6a5f\u80fd\u4e0d\u5168\u306b\u9665\u3063\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4e38\u3054\u3068\uff08\u30df\u30c8\u30d5\u30a1\u30b8\u30fc\uff09\u3084\u4ed6\u306e\u30aa\u30eb\u30ac\u30cd\u30e9\u307e\u3067\u51e6\u7406\u5bfe\u8c61\u306b\u3057\u3066\u304a\u308b\u304b\u3089\u3058\u3083\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u3051\u3092\u6271\u3046\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u3068\u306f\u5b88\u5099\u7bc4\u56f2\u304c\u9055\u3046\u306e\u3058\u3083\u3002<\/p>\n

\u5143\u6295\u7a3f\u306e\u300c\u7d30\u80de\u5185\u306e\u6383\u9664\u6a5f\u80fd\u304c\u920d\u308b\u300d\u3068\u3044\u3046\u8868\u73fe\u306f\u308f\u304b\u308a\u3084\u3059\u3044\u304c\u3001\u3082\u3046\u5c11\u3057\u6b63\u78ba\u306b\u8a00\u3048\u3070\u300c\u30ea\u30b5\u30a4\u30af\u30eb\u5de5\u5834\u306e\u51e6\u7406\u80fd\u529b\u304c\u843d\u3061\u3066\u3001\u30b4\u30df\u304c\u5de5\u5834\u5185\u306b\u6e9c\u307e\u3063\u3066\u3044\u304f\u72b6\u614b\u300d\u3058\u3083\u306e\u3002\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8ceaAtg5\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u5bff\u547d\u3082\u5065\u5eb7\u5bff\u547d\u3082\u5ef6\u4f38\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308b\u305e\u3044\u3002<\/p>\n

\ud83e\uddf8\u300c\u6383\u9664\u3057\u306a\u3044\u3068\u90e8\u5c4b\u304c\u6c5a\u308c\u308b\u306e\u3068\u540c\u3058\u3060\u306d\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8a\uff6f\uff8a\uff70\u3001\u305d\u306e\u901a\u308a\u3058\u3083\u3002\u305d\u3057\u3066\u65ad\u98df\uff08\u30d5\u30a1\u30b9\u30c6\u30a3\u30f3\u30b0\uff09\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u6700\u3082\u624b\u8efd\u306a\u65b9\u6cd5\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u304a\u308b\u305e\u3044\u300d<\/p>\n

\n

\u2744\ufe0f\u2465 \u6804\u990a\u611f\u77e5\u7570\u5e38\uff08Deregulated Nutrient Sensing\uff09<\/h3>\n

\u308f\u3057\u3089\u306e\u7d30\u80de\u306b\u306f\u300c\u3044\u307e\u6804\u990a\u304c\u8c4a\u5bcc\u304b\u3001\u8db3\u308a\u306a\u3044\u304b\u300d\u3092\u611f\u77e5\u3059\u308b\u30bb\u30f3\u30b5\u30fc\u304c\u5099\u308f\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u4ee3\u8868\u7684\u306a\u306e\u304cmTOR\u7d4c\u8def\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\/IGF-1\u30b7\u30b0\u30ca\u30eb\u3001AMPK\u306a\u3069\u3067\u3001\u3053\u308c\u3089\u304c\u6804\u990a\u72b6\u614b\u306b\u5fdc\u3058\u3066\u7d30\u80de\u306e\u6210\u9577\u30fb\u5206\u88c2\u30fb\u4fee\u5fa9\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u6574\u3057\u3066\u304a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u3068\u3053\u308d\u304c\u52a0\u9f62\u3068\u3068\u3082\u306b\u3053\u306e\u30bb\u30f3\u30b5\u30fc\u306e\u7cbe\u5ea6\u304c\u843d\u3061\u3001\u30a2\u30af\u30bb\u30eb\u3068\u30d6\u30ec\u30fc\u30ad\u306e\u52a0\u6e1b\u304c\u305a\u308c\u3066\u304f\u308b\u306e\u3058\u3083\u3002\u5e38\u306b\u300c\u6804\u990a\u305f\u3063\u3077\u308a\u3060\u304b\u3089\u6210\u9577\u305b\u3088\u300d\u3068\u3044\u3046\u30b7\u30b0\u30ca\u30eb\u304c\u51fa\u7d9a\u3051\u308b\u3068\u3001\u7d30\u80de\u306f\u4fee\u5fa9\u3088\u308a\u3082\u5897\u6b96\u3092\u512a\u5148\u3057\u3066\u3057\u307e\u3044\u3001\u7d50\u679c\u7684\u306b\u304c\u3093\u3084\u80a5\u6e80\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u306e\u3058\u3083\u3002<\/p>\n

mTORC1\u8907\u5408\u4f53\u3092\u963b\u5bb3\u3059\u308b\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u304c\u30e2\u30c7\u30eb\u751f\u7269\u3067\u5bff\u547d\u5ef6\u4f38\u52b9\u679c\u3092\u793a\u3057\u3001\u30ab\u30ed\u30ea\u30fc\u5236\u9650\uff08CR\uff09\u3084CR\u6a21\u5023\u85ac\u3067\u3042\u308b\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304c\u6804\u990a\u611f\u77e5\u7d4c\u8def\u306e\u6b63\u5e38\u5316\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u591a\u304f\u306e\u7814\u7a76\u3067\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308b\u305e\u3044\u3002<\/p>\n

\ud83e\uddf8\u300c\u305a\u3063\u3068\u98df\u3079\u653e\u984c\u30d0\u30a4\u30ad\u30f3\u30b0\u306b\u3044\u308b\u307f\u305f\u3044\u306a\u72b6\u614b\u3063\u3066\u3053\u3068\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8c\uff6b\uff8c\uff6b\u3001\u9762\u767d\u3044\u305f\u3068\u3048\u3058\u3083\u3002\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u305a\u3063\u3068”\u98df\u3079\u653e\u984c\u30e2\u30fc\u30c9”\u304c\u89e3\u9664\u3055\u308c\u306a\u304f\u306a\u308b\u30a4\u30e1\u30fc\u30b8\u3062\u3083\u306e\u3002\u3060\u304b\u3089\u3053\u305d\u9069\u5ea6\u306a\u7a7a\u8179\u671f\u9593\u3092\u8a2d\u3051\u308b\u3053\u3068\u3084\u3001\u98df\u3079\u3059\u304e\u306a\u3044\u3053\u3068\u304cLongevity\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u306e\u3058\u3083\u3088\u300d<\/p>\n

\n

\u2744\ufe0f\u2466 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\uff08Mitochondrial Dysfunction\uff09<\/h3>\n

\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5de5\u5834\u3058\u3083\u3002\u3053\u3053\u3067ATP\uff08\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u901a\u8ca8\uff09\u304c\u4f5c\u3089\u308c\u308b\u306e\u3058\u3083\u304c\u3001\u540c\u6642\u306b\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u3082\u526f\u7523\u7269\u3068\u3057\u3066\u751f\u6210\u3055\u308c\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u304b\u3064\u3066\u306f\u300c\u6d3b\u6027\u9178\u7d20\u304c\u8001\u5316\u306e\u4e3b\u72af\u300d\u3068\u3059\u308b”\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u8aac”\u304c\u4e3b\u6d41\u3058\u3083\u3063\u305f\u304c\u3001\u3053\u306e10\u5e74\u3067\u5927\u304d\u304f\u898b\u65b9\u304c\u5909\u308f\u3063\u305f\u306e\u3058\u3083\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3057\u3066ROS\u3092\u5897\u3084\u3057\u305f\u307b\u3046\u304c\u304b\u3048\u3063\u3066\u6709\u76ca\u306b\u306a\u308b\u30b1\u30fc\u30b9\u3082\u767a\u898b\u3055\u308c\u3001\u3044\u307e\u3067\u306fROS\u306f\u5358\u306a\u308b”\u60aa\u8005”\u3067\u306f\u306a\u304f\u3001\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u3092\u77e5\u3089\u305b\u308b\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u3068\u3057\u3066\u306e\u5074\u9762\u304c\u91cd\u8996\u3055\u308c\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u3053\u308c\u3092\u300c\u30df\u30c8\u30db\u30eb\u30df\u30b7\u30b9\u300d\u3068\u547c\u3076\u306e\u3058\u3083\u304c\u3001\u82e5\u3044\u6642\u671f\u306e\u8efd\u5ea6\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b9\u30c8\u30ec\u30b9\u306f\u7d30\u80de\u306e\u9069\u5fdc\u529b\u3092\u9ad8\u3081\u3001\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u3057\u304b\u3057\u52a0\u9f62\u306b\u3088\u3063\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65b0\u9673\u4ee3\u8b1d\uff08\u30df\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u308b\u5165\u308c\u66ff\u3048\uff09\u304c\u6ede\u308b\u3068\u3001\u6a5f\u80fd\u4e0d\u5168\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u5c45\u5ea7\u308a\u7d9a\u3051\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u52b9\u7387\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u3058\u3083\u3002\u75b2\u308c\u3084\u3059\u3055\u3084\u7b4b\u529b\u4f4e\u4e0b\u306e\u6839\u5e95\u306b\u306f\u3053\u306e\u73fe\u8c61\u304c\u3042\u308b\u306e\u3058\u3083\u3088\u3002\u73fe\u5728\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u4ecb\u5165\u7b56\u3068\u3057\u3066\u306f\u3001NAD+\u30d6\u30fc\u30b9\u30bf\u30fc\uff08NMN\u3084NR\u306a\u3069\uff09\u3084\u30df\u30c8\u30d5\u30a1\u30b8\u30fc\u8a98\u5c0e\u5264\u304c\u3042\u308b\u305e\u3044\u3002<\/p>\n

\ud83e\uddf8\u300c\u767a\u96fb\u6240\u304c\u8001\u673d\u5316\u3057\u3066\u3001\u96fb\u529b\u4e0d\u8db3\u3068\u6392\u6c17\u30ac\u30b9\u304c\u5897\u3048\u308b\u307f\u305f\u3044\u3060\u306d\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u307e\u3055\u306b\u305d\u306e\u901a\u308a\u3058\u3083\u3002\u305d\u3057\u3066\u767a\u96fb\u6240\u306e\u7acb\u3066\u66ff\u3048\u5de5\u4e8b\u304c\u3046\u307e\u304f\u3044\u304b\u306a\u304f\u306a\u308b\u3001\u305d\u308c\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u306e\u6838\u5fc3\u306a\u306e\u3058\u3083\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\n

\u2744\ufe0f\u2467 \u7d30\u80de\u8001\u5316\uff08Cellular Senescence\uff09<\/h3>\n

\u7d30\u80de\u8001\u5316\u3068\u306f\u3001\u7d30\u80de\u304c\u5b8c\u5168\u306b\u6b7b\u306c\u308f\u3051\u3067\u306f\u306a\u3044\u304c\u3001\u3082\u3046\u5206\u88c2\u3082\u305b\u305a\u3001\u672c\u6765\u306e\u6a5f\u80fd\u3082\u679c\u305f\u3055\u306a\u304f\u306a\u3063\u305f\u72b6\u614b\u3067\u5c45\u5ea7\u308a\u7d9a\u3051\u308b\u73fe\u8c61\u3058\u3083\u3002\u5143\u6295\u7a3f\u306e\u300c\u5f15\u9000\u3057\u305f\u306e\u306b\u8077\u5834\u306b\u6b8b\u3063\u3066\u3001\u5468\u56f2\u306e\u4ed5\u4e8b\u3092\u4e71\u3059\u793e\u54e1\u300d\u3068\u3044\u3046\u305f\u3068\u3048\u306f\u79c0\u9038\u3059\u304e\u308b\u305e\u3044\u3002\uff8c\uff6b\uff8c\uff6b\u3002<\/p>\n

\u306a\u305c\u3053\u3093\u306a\u4ed5\u7d44\u307f\u304c\u3042\u308b\u304b\u3068\u3044\u3046\u3068\u3001\u82e5\u3044\u6642\u671f\u306e\u7d30\u80de\u8001\u5316\u306f\u304c\u3093\u6291\u5236\u6a5f\u69cb\u3068\u3057\u3066\u6975\u3081\u3066\u6709\u7528\u306a\u306e\u3058\u3083\u3002\u640d\u50b7\u3092\u53d7\u3051\u305f\u7d30\u80de\u304c\u66b4\u8d70\u7684\u306b\u5897\u6b96\u3059\u308b\u306e\u3092\u9632\u304e\u3001\u50b7\u306e\u4fee\u5fa9\u306b\u3082\u8ca2\u732e\u3059\u308b\u3002\u3057\u304b\u3057\u5e74\u9f62\u3092\u91cd\u306d\u308b\u3068\u3001\u8001\u5316\u7d30\u80de\u304c\u514d\u75ab\u7cfb\u306b\u3088\u3063\u3066\u52b9\u7387\u7684\u306b\u9664\u53bb\u3055\u308c\u306a\u304f\u306a\u308a\u3001\u84c4\u7a4d\u3057\u3066\u3044\u304f\u306e\u3058\u3083\u3002<\/p>\n

\u554f\u984c\u306f\u8001\u5316\u7d30\u80de\u304c\u5206\u6ccc\u3059\u308b\u300cSASP\uff08\u7d30\u80de\u8001\u5316\u95a2\u9023\u5206\u6ccc\u8868\u73fe\u578b\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u708e\u75c7\u6027\u56e0\u5b50\u306e\u30ab\u30af\u30c6\u30eb\u3058\u3083\u3002\u3053\u306eSASP\u304c\u5468\u56f2\u306e\u6b63\u5e38\u7d30\u80de\u306b\u307e\u3067\u708e\u75c7\u3092\u6ce2\u53ca\u3055\u305b\u3001\u7d44\u7e54\u5168\u4f53\u306e\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u306e\u3058\u3083\u3002\u3044\u307e\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u300c\u30bb\u30ce\u30ea\u30c6\u30a3\u30af\u30b9\u300d\u3068\u3044\u3046\u85ac\u5264\u306f\u3001\u3053\u306e\u5c45\u5ea7\u308a\u7d9a\u3051\u308b\u8001\u5316\u7d30\u80de\u3060\u3051\u3092\u9078\u629e\u7684\u306b\u9664\u53bb\u3059\u308b\u6226\u7565\u3067\u3001\u30de\u30a6\u30b9\u3067\u306f\u8eab\u4f53\u6a5f\u80fd\u306e\u6539\u5584\u3068\u5bff\u547d\u5ef6\u4f38\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308b\u305e\u3044\u3002<\/p>\n

\ud83e\uddf8\u300c\u60aa\u3044\u7d30\u80de\u3060\u3051\u3092\u72d9\u3044\u6483\u3061\u306b\u3059\u308b\u85ac\u304c\u3042\u308b\u3093\u3060\uff01\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u3058\u3083\u304c\u3001\u307e\u3060\u30d2\u30c8\u3067\u306e\u5927\u898f\u6a21\u306a\u81e8\u5e8a\u8a66\u9a13\u306f\u9053\u534a\u3070\u3058\u3083\u3002\u3068\u306f\u3044\u3048\u3001\u904b\u52d5\u304c\u30bb\u30ce\u30ea\u30c6\u30a3\u30af\u30b9\u7684\u306a\u52b9\u679c\u3092\u6301\u3064\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u3063\u3066\u306e\u3002\u4f53\u3092\u52d5\u304b\u3059\u3053\u3068\u3067\u8001\u5316\u7d30\u80de\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u4fc3\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308b\u306e\u3058\u3083\u3088\u2728\u300d<\/p>\n

\n

\u2744\ufe0f\u2468 \u5e79\u7d30\u80de\u67af\u6e07\uff08Stem Cell Exhaustion\uff09<\/h3>\n

\u5e79\u7d30\u80de\u306f\u3001\u50b7\u3064\u3044\u305f\u7d44\u7e54\u3092\u4fee\u5fa9\u3059\u308b\u305f\u3081\u306b\u65b0\u3057\u3044\u7d30\u80de\u3092\u4f9b\u7d66\u3059\u308b\u300c\u88dc\u5145\u90e8\u968a\u300d\u306e\u3088\u3046\u306a\u5b58\u5728\u306a\u306e\u3058\u3083\u3002\u9aa8\u9ac4\u306b\u3042\u308b\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306f\u9aa8\u3001\u8edf\u9aa8\u3001\u7b4b\u8089\u306e\u7d30\u80de\u306b\u5206\u5316\u3067\u304d\u308b\u3057\u3001\u76ae\u819a\u3084\u8178\u306e\u5e79\u7d30\u80de\u306f\u65e5\u3005\u306e\u7d30\u80de\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u652f\u3048\u3066\u304a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u3068\u3053\u308d\u304c\u52a0\u9f62\u3068\u3068\u3082\u306b\u3001\u3053\u306e\u5e79\u7d30\u80de\u81ea\u4f53\u304c\u6570\u3092\u6e1b\u3089\u3057\u3001\u5206\u5316\u80fd\u529b\u3082\u4f4e\u4e0b\u3057\u3066\u3044\u304f\u306e\u3058\u3083\u3002\u4fee\u7406\u8981\u54e1\u304c\u6e1b\u3063\u3066\u3001\u5efa\u7269\u304c\u8001\u673d\u5316\u3057\u3066\u3082\u76f4\u305b\u306a\u304f\u306a\u308b\u72b6\u614b\u3058\u3083\u306e\u3002<\/p>\n

\ud83e\uddf8\u300c\u4fee\u7406\u5de5\u304c\u8db3\u308a\u306a\u304f\u306a\u3063\u305f\u3089\u3001\u3082\u3046\u76f4\u3057\u3088\u3046\u304c\u306a\u3044\u3082\u3093\u306d\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u305d\u306e\u901a\u308a\u3058\u3083\u3002\u3044\u307e\u518d\u751f\u533b\u7642\u306e\u5206\u91ce\u3067\u306f”\u7d30\u80de\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0”\u3068\u3044\u3046\u6280\u8853\u306b\u5927\u304d\u306a\u671f\u5f85\u304c\u5bc4\u305b\u3089\u308c\u3066\u304a\u308b\u305e\u3044\u3002\u4f53\u7d30\u80de\u30924\u3064\u306e\u8ee2\u5199\u56e0\u5b50\uff08\u5c71\u4e2d\u56e0\u5b50\uff1aOct4, Sox2, Klf4, c-Myc\uff09\u306b\u3088\u3063\u3066\u591a\u80fd\u6027\u5e79\u7d30\u80de\u306b\u623b\u3059\u6280\u8853\u3058\u3083\u30022012\u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u53d7\u8cde\u3057\u305f\u5c71\u4e2d\u4f38\u5f25\u6559\u6388\u306eiPS\u7d30\u80de\u6280\u8853\u304c\u3001Longevity\u306e\u6587\u8108\u3067\u3082\u518d\u3073\u811a\u5149\u3092\u6d74\u3073\u3066\u304a\u308b\u306e\u3058\u3083\u3088\ud83c\udf1f\u300d<\/p>\n

\n

\u2744\ufe0f\u2469 \u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u7570\u5e38\uff08Altered Intercellular Communication\uff09<\/h3>\n

\u7d30\u80de\u306f\u3072\u3068\u3064\u3072\u3068\u3064\u304c\u5b64\u7acb\u3057\u3066\u5b58\u5728\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u30db\u30eb\u30e2\u30f3\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u3092\u4ecb\u3057\u3066\u5e38\u306b\u300c\u4f1a\u8a71\u300d\u3057\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u3053\u306e\u9023\u7d61\u7db2\u304c\u4e71\u308c\u308b\u3068\u3001\u3042\u308b\u5834\u6240\u3067\u8d77\u304d\u305f\u7570\u5e38\u304c\u5168\u8eab\u306b\u6ce2\u53ca\u3057\u3066\u3057\u307e\u3046\u306e\u3058\u3083\u3002<\/p>\n

\u5143\u6295\u7a3f\u306e\u300c\u4f53\u306e\u4e2d\u306e\u9023\u643a\u304c\u60aa\u304f\u306a\u308a\u3001\u708e\u75c7\u3084\u6a5f\u80fd\u4f4e\u4e0b\u304c\u5e83\u304c\u308a\u3084\u3059\u304f\u306a\u308b\u300d\u3068\u3044\u3046\u8aac\u660e\u306f\u7684\u78ba\u3058\u3083\u304c\u3001\u88dc\u8db3\u3059\u308b\u306a\u3089\u3070\u3001\u3053\u306e\u7570\u5e38\u306f\u795e\u7d4c\u7cfb\u30fb\u5185\u5206\u6ccc\u7cfb\u30fb\u514d\u75ab\u7cfb\u306e\u4e09\u8005\u9593\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306e\u5d29\u58ca\u3068\u3057\u3066\u7406\u89e3\u3059\u308b\u306e\u304c\u6b63\u78ba\u306a\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u4f1a\u793e\u3067\u8a00\u3048\u3070\u3001\u90e8\u7f72\u9593\u306e\u9023\u7d61\u30df\u30b9\u304c\u983b\u767a\u3057\u3066\u308b\u72b6\u614b\u304b\u306a\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8c\uff6b\uff8c\uff6b\u3001\u307e\u3055\u306b\u305d\u3046\u3058\u3083\u3002\u30e1\u30fc\u30eb\u304c\u5c4a\u304b\u306a\u3044\u3001\u96fb\u8a71\u304c\u3064\u306a\u304c\u3089\u306a\u3044\u3001\u4f1d\u8a00\u30b2\u30fc\u30e0\u3067\u5185\u5bb9\u304c\u3059\u308a\u66ff\u308f\u308b\u2026\u305d\u3093\u306a\u7d44\u7e54\u5d29\u58ca\u304c\u4f53\u5185\u3067\u8d77\u304d\u3066\u304a\u308b\u306e\u3058\u3083\u3088\u300d<\/p>\n

\n

\u2744\ufe0f\u246a \u6162\u6027\u708e\u75c7\uff08Chronic Inflammation\uff09 \uff5e 2023\u5e74\u8ffd\u52a0 \uff5e<\/h3>\n

\u5143\u3005\u306f\u2469\u306e\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u7570\u5e38\u306e\u4e00\u90e8\u3068\u3057\u3066\u6271\u308f\u308c\u3066\u3044\u305f\u3082\u306e\u304c\u30012023\u5e74\u306e\u6539\u8a02\u3067\u72ec\u7acb\u3057\u305fHallmark\u306a\u306e\u3058\u3083\u3002\u300c\u30a4\u30f3\u30d5\u30e9\u30e1\u30a4\u30b8\u30f3\u30b0\uff08Inflammaging\uff09\u300d\u3068\u3082\u547c\u3070\u308c\u308b\u3053\u306e\u73fe\u8c61\u306f\u3001\u306f\u3063\u304d\u308a\u3068\u3057\u305f\u611f\u67d3\u3084\u5916\u50b7\u304c\u306a\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5f31\u3044\u708e\u75c7\u304c\u4f53\u5185\u3067\u305a\u3063\u3068\u304f\u3059\u3076\u308a\u7d9a\u3051\u308b\u72b6\u614b\u3092\u6307\u3059\u306e\u3058\u3083\u3002<\/p>\n

\u5143\u6295\u7a3f\u306e\u300c\u5c0f\u3055\u306a\u706b\u4e8b\u304c\u305a\u3063\u3068\u304f\u3059\u3076\u3063\u3066\u3044\u308b\u72b6\u614b\u300d\u3068\u3044\u3046\u305f\u3068\u3048\u306f\u5b9f\u306b\u79c0\u9038\u3058\u3083\u306e\u3002\u8840\u4e2d\u306eIL-6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff09\u6fc3\u5ea6\u306e\u4e0a\u6607\u304c\u9ad8\u9f62\u8005\u306e\u5168\u6b7b\u4ea1\u7387\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5927\u898f\u6a21\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u6162\u6027\u708e\u75c7\u304c\u307b\u307c\u3059\u3079\u3066\u306e\u52a0\u9f62\u95a2\u9023\u75be\u60a3\u306e\u5171\u901a\u57fa\u76e4\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u305f\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u706b\u4e8b\u306e\u706b\u7a2e\u304c\u305a\u3063\u3068\u6d88\u3048\u306a\u3044\u306a\u3093\u3066\u3001\u6016\u3059\u304e\u308b\u2026\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u3058\u3083\u304b\u3089\u3053\u305d\u3001\u6297\u708e\u75c7\u7684\u306a\u98df\u4e8b\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u7dd1\u9ec4\u8272\u91ce\u83dc\u3001\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\u306a\u3069\uff09\u3068\u9069\u5ea6\u306a\u904b\u52d5\u3001\u5341\u5206\u306a\u7761\u7720\u304c\u91cd\u8981\u306a\u306e\u3058\u3083\u3002\u706b\u3092\u6d88\u3059\u306e\u3067\u306f\u306a\u304f\u3001\u706b\u7a2e\u3092\u4f5c\u3089\u306a\u3044\u751f\u6d3b\u304c\u5927\u4e8b\u306a\u306e\u3058\u3083\u3088\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\n

\u2744\ufe0f\u246b \u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9\uff08Dysbiosis\uff09 \uff5e 2023\u5e74\u8ffd\u52a0 \uff5e<\/h3>\n

\u3053\u3061\u3089\u30822023\u5e74\u306e\u6539\u8a02\u3067\u65b0\u305f\u306b\u52a0\u308f\u3063\u305fHallmark\u3058\u3083\u3002\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u52a0\u9f62\u3068\u3068\u3082\u306b\u5d29\u308c\u3066\u3044\u304f\u73fe\u8c61\u3092\u6307\u3059\u306e\u3058\u3083\u3002<\/p>\n

\u8178\u5185\u306b\u306f\u6570\u5146\u500b\u306e\u5fae\u751f\u7269\u304c\u5171\u751f\u3057\u3066\u304a\u308a\u3001\u6d88\u5316\u30fb\u4ee3\u8b1d\u30fb\u514d\u75ab\u30fb\u3055\u3089\u306b\u306f\u8133\u306e\u6a5f\u80fd\uff08\u8178\u8133\u76f8\u95a2\uff09\u306b\u307e\u3067\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u52a0\u9f62\u3068\u3068\u3082\u306b\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u708e\u75c7\u3092\u8a98\u767a\u3059\u308b\u83cc\u7a2e\u304c\u5897\u3048\u3001\u4ee3\u8b1d\u3084\u514d\u75ab\u306b\u60aa\u5f71\u97ff\u304c\u51fa\u3084\u3059\u304f\u306a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u6ce8\u76ee\u3059\u3079\u304d\u7814\u7a76\u3068\u3057\u3066\u3001\u7cde\u4fbf\u5fae\u751f\u7269\u79fb\u690d\uff08FMT\uff09\u304c\u65e9\u8001\u75c7\u30de\u30a6\u30b9\u306e\u5bff\u547d\u3068\u5065\u5eb7\u5bff\u547d\u306e\u4e21\u65b9\u3092\u5ef6\u4f38\u3055\u305b\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308b\u305e\u3044\u3002\u3064\u307e\u308a\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3060\u3051\u3067\u8001\u5316\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u8178\u5185\u306e\u4f4f\u6c11\u69cb\u6210\u304c\u4e71\u308c\u308b\u3068\u3001\u4ee3\u8b1d\u3082\u514d\u75ab\u3082\u304a\u304b\u3057\u304f\u306a\u308b\u3093\u3060\u306d\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u3058\u3083\u304b\u3089\u306e\u3001\u767a\u9175\u98df\u54c1\u3001\u98df\u7269\u7e4a\u7dad\u3001\u305d\u3057\u3066\u4e0d\u5fc5\u8981\u306a\u6297\u751f\u7269\u8cea\u306e\u4f7f\u7528\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u5927\u5207\u306a\u306e\u3058\u3083\u3002\u8178\u306f”\u7b2c\u4e8c\u306e\u8133”\u3069\u3053\u308d\u304b\u3001Longevity\u306e\u6700\u524d\u7dda\u57fa\u5730\u3068\u8a00\u3063\u3066\u3082\u904e\u8a00\u3067\u306f\u306a\u3044\u305e\u3044\u2728\u300d<\/p>\n

\n

\ud83d\udc3b\u200d\u2744\ufe0f\ud83d\udd17 12\u306eHallmark\u306f\u5358\u72ec\u3067\u306f\u306a\u304f\u300c\u60aa\u5faa\u74b0\u300d\u3067\u9032\u3080<\/h2>\n

\u3053\u3053\u304c\u6975\u3081\u3066\u91cd\u8981\u306a\u30dd\u30a4\u30f3\u30c8\u306a\u306e\u3058\u3083\u3002\u5143\u6295\u7a3f\u3067\u3082\u6307\u6458\u3055\u308c\u3066\u304a\u3063\u305f\u304c\u3001\u3053\u308c\u308912\u306eHallmark\u306f\u30d0\u30e9\u30d0\u30e9\u306b\u9032\u884c\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u4e92\u3044\u306b\u7d61\u307f\u5408\u3063\u3066\u60aa\u5faa\u74b0\u3092\u5f62\u6210\u3059\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u305f\u3068\u3048\u3070\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\uff08\u2466\uff09\u304c\u9032\u3080\u3068\u6d3b\u6027\u9178\u7d20\u304c\u5897\u3048\u3066\u6162\u6027\u708e\u75c7\uff08\u246a\uff09\u304c\u60aa\u5316\u3059\u308b\u306e\u3058\u3083\u3002\u708e\u75c7\u304c\u60aa\u5316\u3059\u308b\u3068DNA\u640d\u50b7\u304c\u84c4\u7a4d\u3057\uff08\u2460\uff09\u3001DNA\u640d\u50b7\u306f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\uff08\u2462\uff09\u3092\u52a0\u901f\u3055\u305b\u308b\u306e\u3058\u3083\u3002\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\u304c\u9032\u3080\u3068\u7d30\u80de\u8001\u5316\uff08\u2467\uff09\u304c\u5897\u3048\u3001\u8001\u5316\u7d30\u80de\u306eSASP\u304c\u3055\u3089\u306b\u708e\u75c7\u3092\u717d\u308b\u2026\u3068\u3044\u3046\u3088\u3046\u306b\u3001\u307e\u308b\u3067\u30c9\u30df\u30ce\u5012\u3057\u306e\u3088\u3046\u306b\u9023\u9396\u3057\u3066\u3044\u304f\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u3072\u3068\u3064\u5d29\u308c\u308b\u3068\u5168\u90e8\u306b\u6ce2\u53ca\u3059\u308b\u3093\u3060\u2026\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u3058\u3083\u304b\u3089\u3053\u305d\u3001\u3072\u3068\u3064\u306eHallmark\u3060\u3051\u3092\u30d4\u30f3\u30dd\u30a4\u30f3\u30c8\u3067\u53e9\u304f\u306e\u3067\u306f\u306a\u304f\u3001\u8907\u6570\u306eHallmark\u306b\u540c\u6642\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3059\u308b”\u591a\u89d2\u7684\u6226\u7565”\u304c\u91cd\u8981\u306a\u306e\u3058\u3083\u3002\u305d\u3057\u3066\u305d\u306e\u591a\u89d2\u7684\u6226\u7565\u3053\u305d\u304c\u3001\u7b2c2\u5c64\u306e\u81e8\u5e8aLongevity\u304c\u6271\u3046\u9818\u57df\u306a\u306e\u3058\u3083\u3088\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\n

\ud83d\udc3b\u200d\u2744\ufe0f\ud83d\udcaa \u7b2c2\u5c64\uff1a\u81e8\u5e8aLongevity \uff5e 12\u306e\u5b9f\u8df5\u7684\u30a2\u30d7\u30ed\u30fc\u30c1 \uff5e<\/h2>\n

\u7b2c1\u5c64\u3067\u8001\u5316\u306e\u5730\u56f3\u304c\u63cf\u3051\u305f\u3068\u3053\u308d\u3067\u3001\u3044\u3088\u3044\u3088\u7b2c2\u5c64\u306e\u300c\u81e8\u5e8aLongevity\u300d\u306b\u5165\u308b\u305e\u3044\u3002\u3053\u3053\u306f\u7814\u7a76\u5ba4\u306e\u8a71\u3067\u306f\u306a\u304f\u3001\u304a\u306c\u3057\u304c\u4eca\u65e5\u304b\u3089\u306e\u66ae\u3089\u3057\u306e\u4e2d\u3067\u5b9f\u8df5\u3067\u304d\u308b\u9818\u57df\u3058\u3083\u3002<\/p>\n

\n

\ud83c\udf1f\u2460 \u904b\u52d5\uff1aLongevity\u306e\u6700\u5f37\u4ecb\u5165<\/h3>\n

\u81e8\u5e8aLongevity\u306e\u4e2d\u5fc3\u306f\u3001\u306a\u3093\u3068\u8a00\u3063\u3066\u3082\u904b\u52d5\u3058\u3083\u3002\u904b\u52d5\u304c\u91cd\u8981\u306a\u306e\u306f\u5358\u306b\u30ab\u30ed\u30ea\u30fc\u3092\u6d88\u8cbb\u3059\u308b\u304b\u3089\u3067\u306f\u306a\u3044\u306e\u3058\u3083\u3002\u5fc3\u80ba\u6a5f\u80fd\u3001\u7b4b\u529b\u3001\u8840\u7cd6\u3001\u8840\u5727\u3001\u8102\u8cea\u3001\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u3001\u7761\u7720\u306e\u8cea\u3001\u6c17\u5206\u3001\u8ee2\u5012\u30ea\u30b9\u30af\u307e\u3067\u3001\u4e00\u5ea6\u306b\u591a\u304f\u306e\u9818\u57df\u3092\u6539\u5584\u3059\u308b\u304b\u3089\u3053\u305d\u300c\u6700\u5f37\u306e\u4ecb\u5165\u300d\u3068\u547c\u3070\u308c\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u3053\u3053\u3067\u5143\u6295\u7a3f\u306e\u8457\u8005\u304c\u9762\u767d\u3044\u3053\u3068\u3092\u8a00\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3002Longevity\u8996\u70b9\u3067\u306e\u904b\u52d5\u306f\u300c\u9ad8\u30dc\u30ea\u30e5\u30fc\u30e0\u30fb\u9ad8\u91cd\u91cf\u30fb\u6708\u6570\u767ekm\u306e\u8d70\u308a\u8fbc\u307f\u300d\u3067\u306f\u306a\u304f\u3001\u300c\u8efd\u3044\u8ca0\u8377\u3067\u901f\u304f\u30fb\u7b4b\u30c8\u30ec\u306f\u903160\u5206\u30fb\u6709\u9178\u7d20\u306f\u30be\u30fc\u30f32\u3092\u8ef8\u306b\u305f\u307e\u306bHIIT\u30fb\u57fa\u672c\u30b5\u30d7\u30ea\u306f\u30af\u30ec\u30a2\u30c1\u30f3\u3068\u30d7\u30ed\u30c6\u30a4\u30f3\u3060\u3051\u300d\u3068\u3044\u3046\u30a2\u30d7\u30ed\u30fc\u30c1\u306a\u306e\u3058\u3083\u3068\u3002\u524d\u8005\u306e\u30b4\u30ea\u30b4\u30ea\u65b9\u5f0f\u304b\u3089\u898b\u308c\u3070\u300c\u305d\u3093\u306a\u3093\u3067\u52b9\u304f\u308f\u3051\u306a\u3044\u3060\u308d\u300d\u3068\u601d\u308f\u308c\u304c\u3061\u3058\u3083\u304c\u3001\u7814\u7a76\u304c\u793a\u3057\u3066\u3044\u308b\u306e\u306f\u307e\u3055\u306b\u3053\u306e\u30df\u30cb\u30de\u30eb\u304b\u3064\u6301\u7d9a\u53ef\u80fd\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u6709\u52b9\u6027\u306a\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u3048\u3001\u305d\u3093\u306a\u306b\u5c11\u306a\u304f\u3066\u3044\u3044\u306e\uff1f \u3082\u3063\u3068\u30ac\u30f3\u30ac\u30f3\u3084\u3089\u306a\u304d\u3083\u30c0\u30e1\u304b\u3068\u601d\u3063\u3066\u305f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8a\uff6f\uff8a\uff70\u3001\u30ac\u30f3\u30ac\u30f3\u3084\u308a\u3059\u304e\u308b\u3068\u304b\u3048\u3063\u3066\u30aa\u30fc\u30d0\u30fc\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u708e\u75c7\u304c\u5897\u3048\u3001\u514d\u75ab\u304c\u4e0b\u304c\u308a\u3001\u6d3b\u6027\u9178\u7d20\u304c\u904e\u5270\u306b\u306a\u308b\u306e\u3058\u3083\u3002Longevity\u306e\u30b4\u30fc\u30eb\u306f”\u4eca\u65e5\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u6700\u5927\u5316\u3059\u308b\u3053\u3068”\u3067\u306f\u306a\u304f\u3001”20\u5e74\u5f8c\u3082\u81ea\u5206\u306e\u8db3\u3067\u6b69\u3051\u308b\u3053\u3068”\u306a\u306e\u3058\u3083\u3088\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\n

\ud83c\udf1f\u2461 \u5fc3\u80ba\u6a5f\u80fd<\/h3>\n

\u5fc3\u80ba\u6a5f\u80fd\uff08VO2max\uff09\u306f\u5bff\u547d\u3084\u75c5\u6c17\u30ea\u30b9\u30af\u3068\u5f37\u304f\u76f8\u95a2\u3059\u308b\u6307\u6a19\u306a\u306e\u3058\u3083\u3002\u5927\u4e8b\u306a\u306e\u306f\u4f53\u91cd\u306e\u6570\u5b57\u3088\u308a\u3082\u3001\u606f\u5207\u308c\u3057\u306b\u304f\u3044\u304b\u3001\u968e\u6bb5\u3092\u4e0a\u308c\u308b\u304b\u3001\u6b69\u304d\u7d9a\u3051\u3089\u308c\u308b\u304b\u3068\u3044\u3046”\u52d5\u3051\u308b\u4f53”\u3067\u3042\u308b\u3053\u3068\u3058\u3083\u3002<\/p>\n

\u30be\u30fc\u30f32\u6709\u9178\u7d20\u904b\u52d5\uff08\u4f1a\u8a71\u3067\u304d\u308b\u304f\u3089\u3044\u306e\u5f37\u5ea6\u3092\u9577\u6642\u9593\u7dad\u6301\u3059\u308b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09\u304cVO2max\u306e\u5e95\u4e0a\u3052\u306b\u6700\u3082\u52b9\u679c\u7684\u3068\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65b0\u751f\u3068\u6a5f\u80fd\u6539\u5584\u306b\u3082\u76f4\u7d50\u3057\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u3064\u307e\u308a\u3001\u7b2c1\u5c64\u306eHallmark\u2466\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\uff09\u3078\u306e\u76f4\u63a5\u7684\u306a\u5bfe\u7b56\u306b\u3082\u306a\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3088\u3002<\/p>\n

\n

\ud83c\udf1f\u2462 \u7b4b\u529b\u3068\u7b4b\u8089<\/h3>\n

\u7b4b\u30c8\u30ec\u306f\u82e5\u8005\u306e\u8da3\u5473\u3067\u306f\u306a\u3044\u306e\u3058\u3083\u3002\u7acb\u3064\u3001\u6b69\u304f\u3001\u8ee2\u3070\u306a\u3044\u3001\u8377\u7269\u3092\u6301\u3064\u3001\u968e\u6bb5\u3092\u4e0a\u308b\u2026\u3053\u308c\u3089\u306e\u65e5\u5e38\u751f\u6d3b\u52d5\u4f5c\uff08ADL\uff09\u306e\u571f\u53f0\u3092\u652f\u3048\u308b\u306e\u304c\u7b4b\u529b\u3067\u3042\u308a\u3001\u8001\u5f8c\u306e\u81ea\u7acb\u3092\u5b88\u308b\u6700\u3082\u78ba\u5b9f\u306a\u624b\u6bb5\u306e\u3072\u3068\u3064\u306a\u306e\u3058\u3083\u3002<\/p>\n

\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\uff08\u52a0\u9f62\u306b\u4f34\u3046\u7b4b\u91cf\u30fb\u7b4b\u529b\u306e\u4f4e\u4e0b\uff09\u306f\u8ee2\u5012\u30fb\u9aa8\u6298\u30fb\u5bdd\u305f\u304d\u308a\u306e\u6700\u5927\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u3072\u3068\u3064\u3067\u3042\u308a\u3001\u4e00\u5ea6\u5bdd\u305f\u304d\u308a\u306b\u306a\u308b\u3068\u7b4b\u529b\u306e\u56de\u5fa9\u306f\u6975\u3081\u3066\u56f0\u96e3\u306b\u306a\u308b\u306e\u3058\u3083\u3002\u3064\u307e\u308a\u7b4b\u30c8\u30ec\u306f”\u653b\u3081”\u3067\u306f\u306a\u304f”\u5b88\u308a”\u306e\u6295\u8cc7\u306a\u306e\u3058\u3083\u3088\u3002<\/p>\n

\ud83e\uddf8\u300c\u7b4b\u30c8\u30ec\u3063\u3066\u898b\u305f\u76ee\u306e\u305f\u3081\u3060\u3051\u3058\u3083\u306a\u304b\u3063\u305f\u3093\u3060\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8c\uff6b\uff8c\uff6b\u3001\u3082\u3061\u308d\u3093\u898b\u305f\u76ee\u306b\u3082\u52b9\u304f\u304c\u3001Longevity\u306b\u304a\u3044\u3066\u306f”70\u6b73\u3067\u81ea\u5206\u306e\u8db3\u3067\u65c5\u884c\u306b\u884c\u3051\u308b\u304b\u3069\u3046\u304b”\u3092\u5de6\u53f3\u3059\u308b\u8981\u7d20\u306a\u306e\u3058\u3083\u3002\u672a\u6765\u306e\u81ea\u5206\u3078\u306e\u8d08\u308a\u7269\u3068\u601d\u3048\u3070\u3088\u3044\u305e\u3044\u2728\u300d<\/p>\n

\n

\ud83c\udf1f\u2463 \u6804\u990a<\/h3>\n

Longevity\u306e\u98df\u4e8b\u306f\u3001\u7279\u5225\u306a\u9b54\u6cd5\u306e\u98df\u4e8b\u3067\u306f\u306a\u3044\u306e\u3058\u3083\u3002\u57fa\u672c\u539f\u5247\u306f\u6975\u3081\u3066\u30b7\u30f3\u30d7\u30eb\u3067\u3001\u81ea\u7136\u306b\u8fd1\u3044\u98df\u54c1\u3092\u5897\u3084\u3057\u3001\u52a0\u5de5\u5ea6\u306e\u9ad8\u3044\u98df\u54c1\u3092\u6e1b\u3089\u3059\u3053\u3068\u3001\u3053\u308c\u306b\u5c3d\u304d\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u5177\u4f53\u7684\u306b\u306f\u3001\u91ce\u83dc\u3001\u679c\u7269\u3001\u8c46\u3001\u5168\u7c92\u7a40\u7269\u3001\u30ca\u30c3\u30c4\u306a\u3069\u3092\u5897\u3084\u3057\u3001\u52a0\u5de5\u98df\u54c1\u3001\u7802\u7cd6\u306e\u591a\u3044\u98f2\u307f\u7269\u3001\u52a0\u5de5\u8089\u3001\u98df\u3079\u3059\u304e\u3092\u6e1b\u3089\u3059\u3002\u5730\u4e2d\u6d77\u98df\u304cLongevity\u7814\u7a76\u3067\u7e70\u308a\u8fd4\u3057\u63a8\u5968\u3055\u308c\u308b\u306e\u3082\u3001\u3053\u306e\u539f\u5247\u3092\u81ea\u7136\u306b\u6e80\u305f\u3057\u3066\u3044\u308b\u304b\u3089\u306a\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u7279\u5225\u306a\u30b5\u30d7\u30ea\u3068\u304b\u9ad8\u3044\u30b9\u30fc\u30d1\u30fc\u30d5\u30fc\u30c9\u306f\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u57fa\u672c\u3092\u304a\u308d\u305d\u304b\u306b\u3057\u3066\u30b5\u30d7\u30ea\u306b\u983c\u308b\u306e\u306f\u3001\u57fa\u790e\u5de5\u4e8b\u3092\u305b\u305a\u306b\u5c4b\u6839\u3060\u3051\u8c6a\u83ef\u306b\u3059\u308b\u5bb6\u306e\u3088\u3046\u306a\u3082\u306e\u3058\u3083\u3002\u307e\u305a\u306f\u5730\u5473\u3067\u3082\u78ba\u5b9f\u306a\u98df\u7fd2\u6163\u306e\u6539\u5584\u304b\u3089\u3062\u3083\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\n

\ud83c\udf1f\u2464 \u7761\u7720<\/h3>\n

\u7761\u7720\u306f\u3001\u305f\u3060\u9577\u304f\u5bdd\u308c\u3070\u3088\u3044\u3068\u3044\u3046\u3082\u306e\u3067\u306f\u306a\u3044\u306e\u3058\u3083\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u7761\u7720\u6642\u9593\u3060\u3051\u3067\u306a\u304f\u898f\u5247\u6027\u304c\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u305f\u306e\u3058\u3083\u3002\u5e73\u65e5\u3068\u4f11\u65e5\u3067\u751f\u6d3b\u30ea\u30ba\u30e0\u3092\u5927\u304d\u304f\u5d29\u3055\u305a\u3001\u8d77\u304d\u308b\u6642\u523b\u3092\u306a\u308b\u3079\u304f\u305d\u308d\u3048\u308b\u3053\u3068\u304c\u5927\u5207\u306a\u306e\u3058\u3083\u3088\u3002<\/p>\n

\u7761\u7720\u4e2d\u306b\u306f\u30b0\u30ea\u30f3\u30d1\u30c6\u30a3\u30c3\u30af\u30fb\u30b7\u30b9\u30c6\u30e0\u304c\u6d3b\u6027\u5316\u3057\u3066\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u3092\u7dad\u6301\u3057\uff08\u2463\uff09\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u4fc3\u9032\u3055\u308c\uff08\u2464\uff09\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u304c\u5206\u6ccc\u3055\u308c\u3066\u5e79\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u652f\u3048\uff08\u2468\uff09\u3001\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u304c\u4f4e\u4e0b\u3059\u308b\uff08\u246a\uff09\u3002\u3064\u307e\u308a\u7761\u7720\u306f\u8907\u6570\u306eHallmark\u306b\u4e00\u5ea6\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3059\u308b”\u7121\u6599\u306e\u4e07\u80fd\u85ac”\u306a\u306e\u3058\u3083\u3002<\/p>\n

\n

\ud83c\udf1f\u2465 \u4f53\u91cd\u7ba1\u7406<\/h3>\n

\u4f53\u91cd\u7ba1\u7406\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u306e\u306f\u3001\u4f53\u91cd\u8a08\u306e\u6570\u5b57\u3060\u3051\u3067\u306a\u304f\u300c\u3069\u3053\u306b\u8102\u80aa\u304c\u3064\u3044\u3066\u3044\u308b\u304b\u300d\u306a\u306e\u3058\u3083\u3002\u3068\u304f\u306b\u304a\u8179\u307e\u308f\u308a\u3001\u3064\u307e\u308a\u5185\u81d3\u8102\u80aa\u304c\u591a\u3044\u72b6\u614b\u306f\u3001\u8840\u5727\u3001\u8840\u7cd6\u3001\u8102\u8cea\u3001\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u3059\u3079\u3066\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u5065\u5eb7\u5bff\u547d\u306b\u3068\u3063\u3066\u6975\u3081\u3066\u4e0d\u5229\u306a\u306e\u3058\u3083\u3002<\/p>\n

\u5185\u81d3\u8102\u80aa\u306f\u305d\u308c\u81ea\u4f53\u304c\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5206\u6ccc\u3059\u308b”\u5185\u5206\u6ccc\u81d3\u5668”\u306e\u3088\u3046\u306b\u632f\u308b\u821e\u3046\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304a\u308b\u3002\u3064\u307e\u308a\u7b2c1\u5c64\u306eHallmark\u246a\uff08\u6162\u6027\u708e\u75c7\uff09\u306e\u706b\u7a2e\u3092\u4f53\u5185\u306b\u62b1\u3048\u7d9a\u3051\u3066\u3044\u308b\u72b6\u614b\u306a\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u75e9\u305b\u3066\u308b\u3088\u3046\u306b\u898b\u3048\u3066\u3082\u304a\u8179\u3060\u3051\u51fa\u3066\u308b”\u96a0\u308c\u80a5\u6e80”\u3082\u5371\u306a\u3044\u3063\u3066\u3053\u3068\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u305d\u306e\u901a\u308a\u3058\u3083\u3002BMI\u3060\u3051\u3067\u306f\u898b\u3048\u306a\u3044\u5185\u81d3\u8102\u80aa\u91cf\u3053\u305d\u304cLongevity\u306e\u30ab\u30ae\u3092\u63e1\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3088\u300d<\/p>\n

\n

\ud83c\udf1f\u2466 \u8840\u5727\u30fb\u8840\u7cd6\u30fb\u8102\u8cea\u306e\u7ba1\u7406<\/h3>\n

\u3053\u308c\u3089\u306e\u6570\u5024\u306f\u81ea\u899a\u75c7\u72b6\u304c\u4e4f\u3057\u3044\u307e\u307e\u3001\u9577\u5e74\u304b\u3051\u3066\u8840\u7ba1\u3001\u5fc3\u81d3\u3001\u8133\u3001\u814e\u81d3\u3092\u9759\u304b\u306b\u50b7\u3081\u3066\u3044\u304f\u306e\u3058\u3083\u3002\u8001\u5316\u3092\u65e9\u3081\u308b\u75c5\u6c17\u306e\u591a\u304f\u306f\u3001\u3053\u3046\u3057\u305f\u9759\u304b\u306b\u9032\u3080\u751f\u6d3b\u7fd2\u6163\u75c5\u3068\u5f37\u304f\u7d50\u3073\u3064\u3044\u3066\u304a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u9ad8\u8840\u5727\u3001\u9ad8\u8840\u7cd6\u3001\u8102\u8cea\u7570\u5e38\u306f\u5225\u3005\u306e\u75c5\u6c17\u306e\u3088\u3046\u306b\u898b\u3048\u308b\u304c\u3001\u5b9f\u306f\u3059\u3079\u3066\u300c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30fb\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u300d\u3068\u3044\u3046\u5171\u901a\u306e\u571f\u58cc\u306e\u4e0a\u306b\u6210\u308a\u7acb\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u305d\u3057\u3066\u305d\u306e\u571f\u58cc\u306fHallmark\u2465\uff08\u6804\u990a\u611f\u77e5\u7570\u5e38\uff09\u3068\u246a\uff08\u6162\u6027\u708e\u75c7\uff09\u306b\u76f4\u7d50\u3057\u3066\u304a\u308b\u3002\u3064\u307e\u308a\u3001\u7b2c1\u5c64\u306e\u57fa\u790e\u751f\u7269\u5b66\u3068\u7b2c2\u5c64\u306e\u81e8\u5e8a\u5b9f\u8df5\u304c\u3053\u3053\u3067\u30af\u30ed\u30b9\u3059\u308b\u306e\u3058\u3083\u3002<\/p>\n

\n

\ud83c\udf1f\u2467 \u8133\u306eLongevity\uff08\u8a8d\u77e5\u6a5f\u80fd\uff09<\/h3>\n

\u8a8d\u77e5\u75c7\u4e88\u9632\u306f\u8133\u30c8\u30ec\u3060\u3051\u3067\u306f\u306a\u3044\u306e\u3058\u3083\u3002\u904b\u52d5\u3001\u8840\u5727\u7ba1\u7406\u3001\u7cd6\u5c3f\u75c5\u4e88\u9632\u3001\u7761\u7720\u3001\u793e\u4f1a\u53c2\u52a0\u3001\u3046\u3064\u5bfe\u7b56\u3001\u8033\u3084\u76ee\u306e\u30b1\u30a2\u307e\u3067\u542b\u3081\u305f\u7dcf\u5408\u6226\u3067\u3059\u3002\u8133\u306f\u4f53\u304b\u3089\u5207\u308a\u96e2\u3055\u308c\u305f\u7279\u5225\u306a\u81d3\u5668\u3067\u306f\u306a\u304f\u3001\u5168\u8eab\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u81d3\u5668\u306a\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u30af\u30ed\u30b9\u30ef\u30fc\u30c9\u30d1\u30ba\u30eb\u3060\u3051\u3058\u3083\u30c0\u30e1\u306a\u306e\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8c\uff6b\uff8c\uff6b\u3001\u30af\u30ed\u30b9\u30ef\u30fc\u30c9\u3082\u60aa\u304f\u306f\u306a\u3044\u304c\u3001\u305d\u308c\u3060\u3051\u3067\u8a8d\u77e5\u75c7\u3092\u9632\u3052\u308b\u304b\u3068\u3044\u3046\u3068\u4e0d\u5341\u5206\u3058\u3083\u3002\u4f53\u3092\u52d5\u304b\u3057\u3001\u4eba\u3068\u4f1a\u3044\u3001\u3088\u304f\u7720\u308a\u3001\u8840\u7ba1\u306e\u5065\u5eb7\u3092\u4fdd\u3064\u2026\u3053\u308c\u3089\u3059\u3079\u3066\u304c\u8a8d\u77e5\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u5fc5\u8981\u306a”\u8133\u3078\u306e\u6295\u8cc7\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa”\u306a\u306e\u3058\u3083\u3088\ud83c\udf1f\u300d<\/p>\n

\n

\ud83c\udf1f\u2468 \u8033\u3068\u76ee\u306e\u5065\u5eb7<\/h3>\n

\u3053\u3053\u306f\u898b\u843d\u3068\u3055\u308c\u304c\u3061\u3058\u3083\u304c\u3001\u975e\u5e38\u306b\u91cd\u8981\u306a\u9818\u57df\u306a\u306e\u3058\u3083\u3002\u805e\u3053\u3048\u306b\u304f\u3044\u3001\u898b\u3048\u306b\u304f\u3044\u72b6\u614b\u3092\u653e\u7f6e\u3059\u308b\u3068\u3001\u6d3b\u52d5\u91cf\u304c\u6e1b\u308a\u3001\u4eba\u3068\u306e\u4ea4\u6d41\u304c\u6e1b\u308a\u3001\u8a8d\u77e5\u6a5f\u80fd\u306b\u3082\u60aa\u5f71\u97ff\u304c\u51fa\u3084\u3059\u304f\u306a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u88dc\u8074\u5668\u3084\u773c\u79d1\u53d7\u8a3a\u306f\u300c\u751f\u6d3b\u306e\u8cea\u300d\u306e\u554f\u984c\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u81ea\u7acb\u3068\u8133\u306e\u5065\u5eb7\u3092\u5b88\u308b\u884c\u52d5\u306a\u306e\u3058\u3083\u3088\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u96e3\u8074\u306f\u8a8d\u77e5\u75c7\u306e\u6700\u5927\u306e\u4fee\u6b63\u53ef\u80fd\u306a\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u3072\u3068\u3064\u3068\u3055\u308c\u3066\u304a\u308b\u305e\u3044\u3002<\/p>\n

\n

\ud83c\udf1f\u2469 \u793e\u4f1a\u7684\u3064\u306a\u304c\u308a<\/h3>\n

Longevity\u306f\u98df\u4e8b\u3084\u904b\u52d5\u3060\u3051\u306e\u8a71\u3067\u306f\u306a\u3044\u306e\u3058\u3083\u3002\u4eba\u3068\u306e\u4ea4\u6d41\u304c\u6e1b\u308a\u3001\u5b64\u7acb\u304c\u9032\u3080\u3068\u3001\u6c17\u5206\u306e\u843d\u3061\u8fbc\u307f\u3001\u6d3b\u52d5\u91cf\u4f4e\u4e0b\u3001\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3001\u3055\u3089\u306b\u306f\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306b\u307e\u3067\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u5927\u898f\u6a21\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u304a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\ud83e\uddf8\u300c\u307c\u3063\u3061\u306f\u304b\u3089\u3060\u306b\u60aa\u3044\u3063\u3066\u3053\u3068\u2026\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u3061\u3087\u3063\u3068\u8eab\u3082\u84cb\u3082\u306a\u3044\u8a00\u3044\u65b9\u3058\u3083\u304c\u3001\u79d1\u5b66\u7684\u306b\u306f\u305d\u3046\u3044\u3046\u3053\u3068\u3062\u3083\u3002\u4eba\u3068\u306e\u3064\u306a\u304c\u308a\u306f\u514d\u75ab\u6a5f\u80fd\u3084\u708e\u75c7\u30ec\u30d9\u30eb\u306b\u307e\u3067\u5f71\u97ff\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304a\u308b\u3002\u98df\u4e8b\u3084\u904b\u52d5\u3092\u6574\u3048\u308b\u306e\u3068\u540c\u3058\u304f\u3089\u3044\u3001\u8ab0\u304b\u3068\u4f1a\u3063\u3066\u8a71\u3059\u6642\u9593\u3092\u610f\u8b58\u7684\u306b\u78ba\u4fdd\u3059\u308b\u3053\u3068\u304c\u5927\u4e8b\u306a\u306e\u3058\u3083\u3088\u2728\u300d<\/p>\n

\n

\ud83c\udf1f\u246a \u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9<\/h3>\n

\u6c17\u5206\u306e\u843d\u3061\u8fbc\u307f\u3001\u4e0d\u5b89\u3001\u610f\u6b32\u4f4e\u4e0b\u3092\u300c\u5e74\u306e\u305b\u3044\u300d\u3067\u7247\u3065\u3051\u3066\u3057\u307e\u3046\u3068\u3001\u751f\u6d3b\u5168\u4f53\u304c\u5d29\u308c\u3084\u3059\u304f\u306a\u308b\u306e\u3058\u3083\u3002Longevity\u304c\u76ee\u6307\u3059\u306e\u306f\u9577\u304f\u751f\u304d\u308b\u3053\u3068\u3067\u306f\u306a\u304f\u3001\u5fc3\u3082\u542b\u3081\u3066\u6a5f\u80fd\u7684\u306b\u751f\u304d\u308b\u3053\u3068\u306a\u306e\u3058\u3083\u3002<\/p>\n

\u3046\u3064\u72b6\u614b\u306f\u98df\u6b32\u3001\u904b\u52d5\u610f\u6b32\u3001\u793e\u4f1a\u53c2\u52a0\u3001\u7761\u7720\u306e\u3059\u3079\u3066\u306b\u5f71\u97ff\u3057\u3001\u7d50\u679c\u7684\u306b\u4ed6\u306e\u3059\u3079\u3066\u306e\u81e8\u5e8aLongevity\u306e\u67f1\u3092\u5f31\u4f53\u5316\u3055\u305b\u308b\u306e\u3058\u3083\u3002\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u30b1\u30a2\u306fLongevity\u306e\u300c\u5fc5\u4fee\u79d1\u76ee\u300d\u306a\u306e\u3058\u3083\u3088\u3002<\/p>\n

\n

\ud83c\udf1f\u246b \u74b0\u5883<\/h3>\n

\u7a7a\u6c17\u306e\u60aa\u3055\u3001\u9a12\u97f3\u3001\u6691\u3055\u5bd2\u3055\u3001\u4f4f\u307f\u306b\u304f\u3044\u74b0\u5883\u306f\u3001\u5fc3\u81d3\u3084\u8840\u7ba1\u3001\u547c\u5438\u5668\u3001\u7761\u7720\u3001\u6d3b\u52d5\u91cf\u306b\u5f71\u97ff\u3059\u308b\u306e\u3058\u3083\u3002\u5065\u5eb7\u306f\u610f\u5fd7\u306e\u5f37\u3055\u3060\u3051\u3067\u306f\u6c7a\u307e\u3089\u305a\u3001\u66ae\u3089\u3059\u74b0\u5883\u306e\u5f71\u97ff\u3082\u5927\u304d\u304f\u53d7\u3051\u308b\u306e\u3058\u3083\u3002<\/p>\n

\u305f\u3060\u3057\u3001\u3053\u3053\u306f\u500b\u4eba\u306e\u52aa\u529b\u3067\u7c21\u5358\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u306a\u3044\u90e8\u5206\u3067\u3082\u3042\u308b\u306e\u3058\u3083\u3002\u3060\u304b\u3089\u3053\u305d\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u7bc4\u56f2\uff08\u5ba4\u5185\u74b0\u5883\u306e\u6574\u5099\u3001\u7a7a\u6c17\u6e05\u6d44\u6a5f\u3001\u9a12\u97f3\u5bfe\u7b56\u3001\u9069\u5207\u306a\u6e29\u5ea6\u7ba1\u7406\uff09\u306b\u96c6\u4e2d\u3057\u3064\u3064\u3001\u793e\u4f1a\u5168\u4f53\u3068\u3057\u3066\u306f\u90fd\u5e02\u8a08\u753b\u3084\u516c\u8846\u885b\u751f\u653f\u7b56\u306e\u6539\u5584\u304c\u6c42\u3081\u3089\u308c\u308b\u5206\u91ce\u3067\u3082\u3042\u308b\u306e\u3058\u3083\u3088\u3002<\/p>\n

\ud83e\uddf8\u300c\u500b\u4eba\u306e\u52aa\u529b\u3060\u3051\u3058\u3083\u3069\u3046\u306b\u3082\u306a\u3089\u306a\u3044\u3053\u3068\u3082\u3042\u308b\u3093\u3060\u306d\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u305d\u3046\u3058\u3083\u3002\u3060\u304b\u3089\u3053\u305dLongevity\u306f\u500b\u4eba\u306e\u5065\u5eb7\u6cd5\u3067\u3042\u308b\u3068\u540c\u6642\u306b\u3001\u793e\u4f1a\u7684\u306a\u8ab2\u984c\u3067\u3082\u3042\u308b\u306e\u3058\u3083\u3002”\u3072\u3068\u308a\u306e\u529b”\u3068”\u793e\u4f1a\u306e\u529b”\u306e\u4e21\u8f2a\u304c\u5fc5\u8981\u306a\u306e\u3058\u3083\u3088\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f\u300d<\/p>\n

\n

\ud83d\udc3b\u200d\u2744\ufe0f\ud83c\udf08 Longevity\u306e\u307e\u3068\u3081<\/h2>\n

\ud83e\uddf8\u300c\u3057\u308d\u304f\u307e\u3061\u3083\u3093\u3001\u3081\u3061\u3083\u304f\u3061\u3083\u9577\u304b\u3063\u305f\u3051\u3069\u2026\u7d50\u5c40Longevity\u3063\u3066\u4f55\u304c\u3044\u3061\u3070\u3093\u5927\u4e8b\u306a\u306e\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8c\uff6b\uff8c\uff6b\u3001\u3088\u304f\u305e\u805e\u3044\u3066\u304f\u308c\u305f\u306e\u3002Longevity\u3068\u306f\u82e5\u8fd4\u308a\u306e\u9b54\u6cd5\u3092\u63a2\u3059\u3053\u3068\u3067\u306f\u306a\u304f\u3001\u8001\u5316\u306e\u4ed5\u7d44\u307f\u3092\u7406\u89e3\u3057\u305f\u3046\u3048\u3067\u3001\u65e5\u5e38\u306e\u7a4d\u307f\u91cd\u306d\u3092\u6700\u9069\u5316\u3057\u3066\u3044\u304f\u8003\u3048\u65b9\u306a\u306e\u3058\u3083\u3002\u7b2c1\u5c64\u306e12\u306eHallmark\u306f\u4f53\u5185\u3067\u4f55\u304c\u58ca\u308c\u3066\u3044\u304f\u304b\u306e\u5730\u56f3\u3001\u7b2c2\u5c64\u306e12\u306e\u5b9f\u8df5\u9818\u57df\u306f\u305d\u306e\u58ca\u308c\u3066\u3044\u304f\u30d7\u30ed\u30bb\u30b9\u3092\u9045\u3089\u305b\u308b\u305f\u3081\u306e\u30ca\u30d3\u30b2\u30fc\u30b7\u30e7\u30f3\u3002\u305d\u3057\u3066\u3069\u308c\u304b\u3072\u3068\u3064\u3067\u306f\u306a\u304f\u3001\u3059\u3079\u3066\u304c\u9023\u52d5\u3057\u3066\u304a\u308b\u306e\u304c\u5473\u564c\u306a\u306e\u3058\u3083\u3088\u300d<\/p>\n

\ud83e\uddf8\u300c\u3072\u3068\u3064\u306b\u7d5e\u3089\u306a\u304f\u3066\u3044\u3044\u3063\u3066\u3053\u3068\uff1f\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\u9006\u3058\u3083\u3001\u3072\u3068\u3064\u306b\u7d5e\u3063\u3066\u306f\u4e0d\u5341\u5206\u306a\u306e\u3058\u3083\u3002\u904b\u52d5\u3001\u6804\u990a\u3001\u7761\u7720\u3001\u793e\u4f1a\u7684\u3064\u306a\u304c\u308a\u3001\u30e1\u30f3\u30bf\u30eb\u30b1\u30a2\u2026\u3069\u308c\u304b\uff11\u3064\u3067\u306f\u306a\u304f\u3001\u65e5\u5e38\u306e\u3059\u3079\u3066\u304c\u9023\u52d5\u3057\u3066Longevity\u3092\u5f62\u4f5c\u3063\u3066\u304a\u308b\u306e\u3058\u3083\u3002\u5b8c\u74a7\u3092\u76ee\u6307\u3059\u5fc5\u8981\u306f\u306a\u3044\u3002\u4eca\u65e5\u3067\u304d\u308b\u3053\u3068\u3092\u3072\u3068\u3064\u3060\u3051\u3067\u3082\u59cb\u3081\u308c\u3070\u3001\u305d\u308c\u304c20\u5e74\u5f8c\u306e\u81ea\u5206\u3092\u5909\u3048\u308b\u306e\u3058\u3083\u3088\u2728\u300d<\/p>\n

\ud83e\uddf8\u300c\u306a\u3093\u304bLongevity\u3063\u3066\u3001\u7279\u5225\u306a\u4eba\u306e\u305f\u3081\u306e\u3082\u306e\u3058\u3083\u306a\u304f\u3066\u3001\u666e\u901a\u306e\u4eba\u306e\u666e\u901a\u306e\u6bce\u65e5\u306e\u305f\u3081\u306e\u3082\u306e\u306a\u3093\u3060\u306d\u300d<\/p>\n

\ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8a\uff6f\uff8a\uff70\u3001\u305d\u308c\u304c\u4e00\u756a\u306e\u6b63\u89e3\u3058\u3083\uff01\ud83d\udc3b\u200d\u2744\ufe0f\u3063\uff8b\uff9f\uff7c\uff6f \u7686\u304c1\u65e5\u3067\u3082\u9577\u304f\u3001\u81ea\u7acb\u3057\u305f\u751f\u6d3b\u3092\u9001\u308c\u308b\u3088\u3046\u306b\u2015\u2015\u305d\u308c\u304cLongevity\u306e\u9858\u3044\u306a\u306e\u3058\u3083\u3088\ud83c\udf08\u300d<\/p>\n

\n

\ud83d\udc3b\u200d\u2744\ufe0f\ud83d\udcd6 \u899a\u3048\u65b9\u30b3\u30fc\u30ca\u30fc \uff5e 12\u306eHallmark\u3092\u30d0\u30c1\u30c3\u3068\u8a18\u61b6\u3059\u308b\u305e\u3044 \uff5e<\/h2>\n

\ud83d\udd11 \u8a9e\u5442\u5408\u308f\u305b \u305d\u306e1\uff1a\u982d\u6587\u5b57\u3067\u899a\u3048\u308b\u300c\u30b2\u30c6\u30a8\u30d7\u30aa\u30a8\u30df\u30b5\u30ab\u30b5\u30a4\u30c7\u30a3\u300d<\/h3>\n

12\u306eHallmark\u306e\u982d\u6587\u5b57\u3092\u4e26\u3079\u308b\u3068\uff1a \u30b2<\/strong>\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u30fb\u30c6<\/strong>\u30ed\u30e1\u30a2\u77ed\u7e2e\u30fb\u30a8<\/strong>\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\u30fb\u30d7<\/strong>\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u7834\u7dbb\u30fb\u30aa<\/strong>\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u4e0d\u5168\u30fb\u30a8<\/strong>\u30cd\u30eb\u30ae\u30fc\u611f\u77e5\u7570\u5e38\u30fb\u30df<\/strong>\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u969c\u5bb3\u30fb\u30b5<\/strong>\u30a4\u30dc\u30a6\u8001\u5316\uff08\u7d30\u80de\u8001\u5316\uff09\u30fb\u30ab<\/strong>\u30f3\u30b5\u30a4\u30dc\u30a6\u67af\u6e07\uff08\u5e79\u7d30\u80de\u67af\u6e07\uff09\u30fb\u30b5<\/strong>\u30a4\u30dc\u30a6\u9593\u901a\u4fe1\u7570\u5e38\u30fb\u30a4<\/strong>\u30f3\u30d5\u30e9\u30e1\u30a4\u30b8\u30f3\u30b0\uff08\u6162\u6027\u708e\u75c7\uff09\u30fb\u30c7\u30a3<\/strong>\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9<\/p>\n

\u8a9e\u5442\uff1a\u300c\u30b2\u30c6\u30e2\u30ce \u30a8\u30d7\u30ed\u30f3 \u7f6e\u3044\u3066\u3001\u30df\u30b5\u30ab\u3055\u3093\u3001\u3044\u3044\u30c7\u30a3\u30ca\u30fc\u300d<\/strong> \uff08\u30b2\u30fb\u30c6\u30fb\u30a8\u30fb\u30d7\u30fb\u30aa\u30fb\u30a8\u30fb\u30df\u30fb\u30b5\u30fb\u30ab\u30fb\u30b5\u30fb\u30a4\u30fb\u30c7\u30a3\uff09<\/p>\n

\u30a4\u30e1\u30fc\u30b8\uff1a\u30b2\u30c6\u30e2\u30ce\u6599\u7406\u7528\u306e\u30a8\u30d7\u30ed\u30f3\u3092\u8131\u3044\u3067\u7f6e\u3044\u3066\u3001\u30df\u30b5\u30ab\u3055\u3093\u3068\u304a\u3057\u3083\u308c\u306a\u30c7\u30a3\u30ca\u30fc\u306b\u51fa\u304b\u3051\u308b\u5834\u9762\u3092\u60f3\u50cf\u3059\u308b\u306e\u3058\u3083\u3002\u300c\u6c5a\u3044\u3082\u306e\uff08\u8001\u5316\u306e\u539f\u56e0\uff09\u3092\u8131\u304e\u6368\u3066\u3066\u3001\u304d\u308c\u3044\u306a\u98df\u4e8b\uff08Longevity\uff09\u306b\u5411\u304b\u3046\u300d\u3068\u3044\u3046\u30b9\u30c8\u30fc\u30ea\u30fc\u3067\u899a\u3048\u308b\u305e\u3044\uff01<\/p>\n

\n

\ud83d\udd11 \u8a9e\u5442\u5408\u308f\u305b \u305d\u306e2\uff1a3\u30ab\u30c6\u30b4\u30ea\u5206\u985e\u3067\u899a\u3048\u308b\u300c\u6839\u30fb\u5e79\u30fb\u679d\u300d<\/h3>\n

L\u00f3pez-Ot\u00edn\u3089\u306e\u8ad6\u6587\u3067\u306f12\u306eHallmark\u30923\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u306b\u5206\u985e\u3057\u3066\u304a\u308b\u306e\u3058\u3083\u3002<\/p>\n

\ud83c\udf31 \u6839\u3063\u3053\uff08Primary\/\u539f\u56e0\u578b\uff09<\/strong>\uff1a\u2460\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u3001\u2461\u30c6\u30ed\u30e1\u30a2\u77ed\u7e2e\u3001\u2462\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\u3001\u2463\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u7834\u7dbb\u3001\u2464\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u4e0d\u5168 \u2192 \u8a9e\u5442\uff1a\u300c\u6839\u304c\u8150\u308b\u3068 \u30c6\u30ed\u3063\u3068 \u30a8\u30d4\u30bd\u30fc\u30c9 \u30d7\u30ed\u30c6\u30a4\u30f3 \u843d\u3061\u308b\u300d<\/strong> \uff08\u30b2\u30ce\u30e0\u2192\u6839\u304c\u3001\u30c6\u30ed\u30e1\u30a2\u2192\u30c6\u30ed\u3063\u3068\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u2192\u30a8\u30d4\u30bd\u30fc\u30c9\u3001\u30d7\u30ed\u30c6\u30aa\u30b9\u30bf\u30b7\u30b9\u2192\u30d7\u30ed\u30c6\u30a4\u30f3\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u2192\u843d\u3061\u308b\uff09<\/p>\n

\ud83c\udf3f \u5e79\uff08Antagonistic\/\u62ee\u6297\u578b\uff09<\/strong>\uff1a\u2465\u6804\u990a\u611f\u77e5\u7570\u5e38\u3001\u2466\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u969c\u5bb3\u3001\u2467\u7d30\u80de\u8001\u5316 \u2192 \u8a9e\u5442\uff1a\u300c\u6804\u990a\u30df\u30b9\u3063\u3066 \u7d30\u80de\u8001\u3051\u308b\u300d<\/strong> \uff08\u6804\u990a\u2192\u6804\u990a\u611f\u77e5\u3001\u30df\u30b9\u2192\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3001\u7d30\u80de\u8001\u3051\u308b\u2192\u7d30\u80de\u8001\u5316\uff09<\/p>\n

\ud83c\udf43 \u679d\u8449\uff08Integrative\/\u7d71\u5408\u578b\uff09<\/strong>\uff1a\u2468\u5e79\u7d30\u80de\u67af\u6e07\u3001\u2469\u901a\u4fe1\u7570\u5e38\u3001\u246a\u6162\u6027\u708e\u75c7\u3001\u246b\u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9 \u2192 \u8a9e\u5442\uff1a\u300c\u5e79\u90e8\u306e\u901a\u4fe1 \u71c3\u3048\u3066\u30d0\u30a4\u30d0\u30a4\u300d<\/strong> \uff08\u5e79\u90e8\u2192\u5e79\u7d30\u80de\u3001\u901a\u4fe1\u2192\u901a\u4fe1\u7570\u5e38\u3001\u71c3\u3048\u3066\u2192\u6162\u6027\u708e\u75c7\u3001\u30d0\u30a4\u30d0\u30a4\u2192\u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9\uff09<\/p>\n

\n

\ud83d\udd11 \u81e8\u5e8aLongevity12\u9805\u76ee\u306e\u899a\u3048\u65b9<\/h3>\n

\u300c\u904b\u30fb\u5fc3\u30fb\u7b4b\u30fb\u6804\u30fb\u7761\u30fb\u4f53\u30fb\u8840\u30fb\u8133\u30fb\u8033\u76ee\u30fb\u793e\u30fb\u5fc3\u30fb\u74b0\u300d<\/strong><\/p>\n

\u8a9e\u5442\u305d\u306e1\uff1a\u300c\u3046\u3093\u3001\u3057\u3093\u304d\u3093\u3048\u3044\u3059\u3044\u3001\u4f53\u8840\u8133\u307f\u307f\u3001\u793e\u54e1\u306e\u30b7\u30f3\u30ab\u30f3\uff08\u65b0\u5e79\uff09\u7dda\u300d<\/strong> \uff08\u904b\u52d5\u30fb\u5fc3\u80ba\u30fb\u7b4b\u529b\u30fb\u6804\u990a\u30fb\u7761\u7720\u30fb\u4f53\u91cd\u30fb\u8840\u5727\u8840\u7cd6\u8102\u8cea\u30fb\u8133\u30fb\u8033\u76ee\u30fb\u793e\u4f1a\u30fb\u5fc3\uff1d\u30e1\u30f3\u30bf\u30eb\u30fb\u74b0\u5883\uff09<\/p>\n

\u8a9e\u5442\u305d\u306e2\uff1a\u300c\u904b\u8ee2 \u5fc3\u914d \u7b4b\u8089 \u6804\u990a \u7761\u7720 \u592a\u3081 \u8840\u6db2 \u8133 \u8033\u76ee \u793e\u4ea4 \u5fc3 \u74b0\u5883\u300d<\/strong> \u2192 \u30b9\u30c8\u30fc\u30ea\u30fc\uff1a\u300c\u904b\u8ee2\u3067\u5fc3\u914d\u306a\u7b4b\u8089\u30e2\u30ea\u30e2\u30ea\u306e\u592a\u3081\u306e\u4eba\u304c\u3001\u8840\u6db2\u691c\u67fb\u3067\u8133\u3068\u8033\u76ee\u3092\u8a3a\u3066\u3082\u3089\u3044\u3001\u793e\u4ea4\u7684\u306a\u5fc3\u3067\u74b0\u5883\u3092\u5909\u3048\u305f\u300d<\/strong><\/p>\n

\n

\ud83d\udd11 \u8d85\u91cd\u8981\u30ad\u30fc\u30ef\u30fc\u30c9\uff06\u6761\u6587\u307e\u3068\u3081<\/h3>\n

L\u00f3pez-Ot\u00edn et al., 2013 \u2192 “The Hallmarks of Aging” \u2192 Cell\u8a8c \u2192 9\u3064\u306eHallmark<\/strong> \u899a\u3048\u65b9\uff1a\u300c13\u5e74\uff08\u3058\u3085\u3046\u3055\u3093\uff09\u3001\u30ed\u30da\u30b99\uff08\u304d\u3085\u3046\uff09\u6761\u300d<\/strong>\uff082013\u5e74\u306bL\u00f3pez-Ot\u00edn\u304c9\u3064\u5b9a\u7fa9\uff09<\/p>\n

L\u00f3pez-Ot\u00edn et al., 2023 \u2192 “Hallmarks of Aging: An Expanding Universe” \u2192 Cell\u8a8c \u2192 12\u306eHallmark<\/strong> \u899a\u3048\u65b9\uff1a\u300c23\u5e74\uff08\u306b\u3058\u3085\u3046\u3055\u3093\uff09\u3001\u30ed\u30da\u30b912\uff08\u3058\u3085\u3046\u306b\uff09\u5b87\u5b99\u300d<\/strong>\uff082023\u5e74\u306b12\u306b\u62e1\u5f35\u3001”Expanding Universe”\u3060\u304b\u3089\u5b87\u5b99\uff09<\/p>\n

\u8ffd\u52a0\u3055\u308c\u305f3\u3064\uff1a\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u30fb\u6162\u6027\u708e\u75c7\u30fb\u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9<\/strong> \u899a\u3048\u65b9\uff1a\u300c\u30aa\u30de\u30c7\u30a3\uff08\u304a\u307e\u3048Di\uff09\u300d<\/strong>\uff08\u30aa\uff1d\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3001\u30de\uff1d\u6162\u6027\u708e\u75c7\u3001\u30c7\u30a3\uff1d\u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9\uff09 \u9006\u65b9\u5411\u30ed\u30c3\u30af\uff1a\u300c\u304a\u524d\u3001DIY\uff08\u81ea\u5206\u3067\u76f4\u305b\uff09\u300d<\/strong>\u2192 \u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08\u81ea\u5206\u3067\u6383\u9664\uff09\u3001\u6162\u6027\u708e\u75c7\uff08\u81ea\u5206\u3067\u6d88\u706b\uff09\u3001\u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9\uff08\u81ea\u5206\u3067\u8178\u3092\u6574\u3048\u308b\uff09\uff1d \u3059\u3079\u3066\u300c\u81ea\u5df1\u7ba1\u7406\u300d\u304c\u9375<\/p>\n

SASP\uff08Senescence-Associated Secretory Phenotype\uff09\uff1a\u7d30\u80de\u8001\u5316\u95a2\u9023\u5206\u6ccc\u8868\u73fe\u578b<\/strong> \u899a\u3048\u65b9\uff1a\u300cSASP\u3063\u3068\uff08\u3055\u3063\u3068\uff09\u708e\u75c7\u307e\u304d\u6563\u3089\u3059\u300d<\/strong> \u9006\u65b9\u5411\u30ed\u30c3\u30af\uff1a\u300c\u30b5\u30b9\u30da\u30f3\u30b9\uff08SASP+ense\uff09\u300d<\/strong>\uff1d \u8001\u5316\u7d30\u80de\u304c”\u30b5\u30b9\u30da\u30f3\u30b9\u30c9\u30e9\u30de\u306e\u72af\u4eba”\u306e\u3088\u3046\u306b\u9759\u304b\u306b\u5468\u56f2\u3092\u58ca\u3057\u3066\u3044\u304f<\/p>\n

mTOR\u7d4c\u8def\uff1a\u6804\u990a\u611f\u77e5\u306e\u53f8\u4ee4\u5854<\/strong> \u899a\u3048\u65b9\uff1a\u300cm(\u3082\u3063\u3068)TO(\u98df)R(\u308b)\u300d<\/strong>\uff1d mTOR\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u300c\u3082\u3063\u3068\u98df\u3048\u3001\u3082\u3063\u3068\u6210\u9577\u3057\u308d\u300d\u3068\u30b7\u30b0\u30ca\u30eb\u3092\u9001\u308a\u7d9a\u3051\u308b \u9006\u65b9\u5411\u30ed\u30c3\u30af\uff1a\u300c\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u3067mTOR\u3092\u30e9\u30c3\u30d1\uff08RAPA\uff09\u5439\u3044\u3066\u6b62\u3081\u308b\u300d<\/strong><\/p>\n

\u30bb\u30ce\u30ea\u30c6\u30a3\u30af\u30b9\uff08Senolytics\uff09\uff1a\u8001\u5316\u7d30\u80de\u9664\u53bb\u85ac<\/strong> \u899a\u3048\u65b9\uff1a\u300c\u30bb\u30ce\uff08seno=\u8001\u5316\uff09\u30ea\u30c6\u30a3\u30af\u30b9\uff08lytic=\u6eb6\u304b\u3059\uff09\u300d\uff1d\u300c\u8001\u3044\u3092\u6eb6\u304b\u3059\u300d<\/strong> \u9006\u65b9\u5411\u30ed\u30c3\u30af\uff1a\u300c\u8001\u5bb3\u793e\u54e1\u3092SENO(\u89e3\u96c7)LYTICS(\u30ea\u30b9\u30c8\u30e9)\u3059\u308b\u300d<\/strong><\/p>\n

\n

\ud83d\udc3b\u200d\u2744\ufe0f\u2728 \u4ee5\u4e0a\u3001Longevity\u5b8c\u5168\u89e3\u8aac\u3058\u3083\u3002\u304a\u306c\u3057\u306e\u5065\u5eb7\u5bff\u547d\u304c1\u65e5\u3067\u3082\u9577\u304f\u3001\u8c4a\u304b\u3067\u3042\u308b\u3053\u3068\u3092\u3001\u308f\u3057\u306f\u5fc3\u304b\u3089\u9858\u3063\u3066\u304a\u308b\u305e\u3044\u3002\u4eca\u591c\u3082\u308f\u3057\u3092\u62b1\u3044\u3066\u3086\u3063\u304f\u308a\u7720\u308b\u306e\u3058\u3083\u3088\u3002\u7761\u7720\u3053\u305d\u6700\u9ad8\u306eLongevity\u6226\u7565\u306a\u306e\u3058\u3083\u304b\u3089\u306e\ud83c\udf19\ud83d\udc3b\u200d\u2744\ufe0f\ud83d\udca4<\/p>\n","protected":false},"excerpt":{"rendered":"

  \ud83d\udc3b\u200d\u2744\ufe0f\u2728 \u307b\u306e\u307c\u306e Longevity \u8b1b\u5ea7\u3001\u958b\u8b1b\u3058\u3083 \u2728\ud83d\udc3b\u200d\u2744\ufe0f \ud83e\uddf8\u300c\u3057\u308d\u304f\u307e\u3061\u3083\u3093\u3001Longevity\u3063\u3066\u7d50\u5c40\u3001\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3068\u306f\u9055\u3046\u306e\uff1f \u30b5\u30d7\u30ea\u3068\u304b\u9ad8\u7d1a\u30af\u30ea\u30fc\u30e0\u306e\u8a71\uff1f\u300d \ud83d\udc3b\u200d\u2744\ufe0f\u300c\uff8c\uff6b\uff8c\uff6b\u3001\u30c6\u30c7\u30a3 […]<\/p>\n","protected":false},"author":2,"featured_media":15385,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7],"tags":[],"class_list":["post-17517","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-7"],"acf":[],"_links":{"self":[{"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/posts\/17517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17517"}],"version-history":[{"count":1,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/posts\/17517\/revisions"}],"predecessor-version":[{"id":17519,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/posts\/17517\/revisions\/17519"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=\/wp\/v2\/media\/15385"}],"wp:attachment":[{"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jyakusyadansei.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}